PMID: 6107064Sep 1, 1980Paper

Cerebral circulatory and metabolic responses to intravenously administered lorazepam

Anesthesiology
M A RockoffL F Marshall

Abstract

Cerebral vascular and metabolic effects of lorazepam were evaluated in ten awake monkeys by use of a modification of the Kety-Schmidt technique. Five received ketamine, 10 mg/kg, im, five to eight hours prior to the study, but all animals were otherwise treated identically. Monkeys receiving ketamine had significantly greater (P < 0.05) cerebral blood flow (CBF) values before lorazepam was given (46 +/- 1 ml/100 g/min) than did monkeys not receiving ketamine (41 +/- 1 ml/100 g/min), but in all other respects, premedicated and unpremedicated animals did not differ. Lorazepam administration did not significantly alter systemic arterial blood pressure or blood-gas values. However, it did decrease CBF by 26 per cent and increase cerebral vascular resistance (CVR) by approximately 25 per cent (P < 0.01). The cerebral metabolic rate for glucose (CMRg) decreased 42 per cent (P < 0.05). Following lorazepam administration, the cerebral metabolic rate for oxygen (CMRO2) decreased by 21-30 per cent. When combined CMRO2 data for the two anesthetic groups are pooled, this decrease is significant (P < 0.05). This study indicates that sedative doses of lorazepam decrease cerebral blood flow and metabolism with minimal effects on blood pressur...Continue Reading

Citations

May 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J C Drummond
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·M L JackR A O'Brien
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·E MatthewS M Paul
Aug 1, 1992·Journal of Pharmaceutical Sciences·W R BanksG A Digenis
Oct 16, 2015·Journal of Neurosurgical Anesthesiology·Frederick A ZeilerColin J Kazina
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·M Mamelak
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A ForsterD Morel
Aug 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N L FosterB W Agranoff
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·R E OrenE H Rubinstein
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·D ReicherE H Rubinstein
Jul 16, 2019·Critical Care Medicine·David C SamuelsTimothy D Girard
Dec 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·R J MathewM L Weinman

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