Cerebral distribution of white matter lesions in migraine with aura patients

Cephalalgia : an International Journal of Headache
G RossatoSAM study group

Abstract

The objective of the study was to compare the cerebral distribution of white matter lesions (WMLs) between migraine patients with different aura symptoms. Migraine with aura (MA) patients were consecutively enrolled as part of the Shunt-Associated Migraine (SAM) study. According to clinical symptoms, aura was classified as motor, aphasic, sensory, visual or vertebrobasilar. Standard and FLAIR (fluid attenuated inversion recovery) T(2)-weighted MRI sequences were inspected for WMLs by three independent raters blinded to clinical data. WMLs were assessed in the periventricular areas (PV-WMLs) with the Fazekas scale and in the deep white matter (D-WMLs) with the Schelten's scale. Interobserver agreement was good to excellent (k = 0.64 to 0.96, p < .0001). One hundred and eighty-five patients (77% women) were included. Aura symptoms were classified as visual in 172 (99%) patients, sensory in 76 (42%), aphasic in 54 (30%), motor in 39 (21%) and vertebrobasilar in 17 (9%) patients. One hundred and four patients (57%) exhibited more than one type of aura. D-WMLs were mainly detected in the frontal lobes (86%). There was no association between type of aura and the presence of WMLs in any cerebral location. Aura symptoms do not influenc...Continue Reading

References

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Citations

Jun 21, 2012·Journal of Neurology·Martina AbsintaMassimo Filippi
May 3, 2014·Obstetrics and Gynecology·Marjon J WiegmanJan C de Groot
Apr 23, 2014·Current Opinion in Neurology·Anders HougaardMessoud Ashina
Aug 11, 2017·The International Journal of Neuroscience·Rachel GaliotoDale S Bond
Oct 10, 2018·Neurologia i neurochirurgia polska·Iwona Rościszewska-ŻukowskaPiotr Janik
May 15, 2012·Neurologia i neurochirurgia polska·Maria Łukasik, Wojciech Kozubski
Sep 22, 2018·The Egyptian Journal of Neurology, Psychiatry and Neurosurgery·Mohamed NegmAlshimaa Asran
Apr 7, 2018·Current Medicinal Chemistry·Antonio RussoGioacchino Tedeschi

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