PMID: 2505159Sep 1, 1989Paper

Cerebral edema induced by arachidonic acid: role of leukocytes and 5-lipoxygenase products

Neurosurgery
S M PapadopoulosJ T Hoff

Abstract

Arachidonic acid is released from cellular phospholipid membranes after brain injury associated with vasogenic edema. Intracerebral injection of arachidonic acid results in rapid breakdown of the blood-brain barrier, followed by an increase in brain water and sodium content. This effect is diminished by a 5-lipoxygenase inhibitor, but is unaffected by indomethacin, an inhibitor of cyclooxygenase. Leukocytes are rich in 5-lipoxygenase and mediate posttraumatic extracellular edema in other tissues. We sought to determine whether leukocytes are necessary for arachidonic acid-induced vasogenic edema and whether they are the primary source of 5-lipoxygenase activity. Intracerebral injection of arachidonic acid (10 micrograms) was performed in 21 rats divided into three groups. One hour after injection, the area of Evans blue stain extravasation on the corona slice through the needle tract was quantitated by polar planimetry and taken as a measure of blood-brain barrier permeability. Control animals (n = 7) had a 3.44 +/- 0.19 mm2 area of Evans blue cortical stain. Rats (n = 7) pretreated with a lipoxygenase inhibitor (BW755C) had a significant decrease (P less than 0.05) in the area of Evans blue extravasation was not significantly ...Continue Reading

Citations

Aug 1, 1992·Acta Neurologica Scandinavica·P GaetaniR Rodriguez y Baena
Feb 8, 2006·Neurosurgery·Narendra NathooMladen Golubic
Jun 30, 2011·Free Radical Biology & Medicine·Paul A Fraser
Jun 12, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chikako NitoPak H Chan
May 1, 1991·Journal of Neurosurgery·J E BailesL Manack
Feb 6, 1998·Journal of Neurosurgery·Y HirashimaA Takaku
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·P M Kochanek, J M Hallenbeck
Feb 1, 1991·Stroke; a Journal of Cerebral Circulation·P GaetaniR Rodriguez y Baena
May 1, 2009·Acta Neuropathologica·Sukriti NagDuncan J Stewart

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