Cerebral effects of cold reperfusion after hypothermic circulatory arrest

The Journal of Thoracic and Cardiovascular Surgery
M P EhrlichR B Griepp

Abstract

This study was undertaken to explore whether an interval of cold reperfusion can improve cerebral outcome after prolonged hypothermic circulatory arrest. Sixteen pigs (27-30 kg) underwent 90 minutes of circulatory arrest at a brain temperature of 20 degrees C. Eight animals were rewarmed immediately after hypothermic circulatory arrest (controls), and 8 were reperfused for 20 minutes at 20 degrees C and then rewarmed (cold reperfusion). Electrophysiologic recordings, fluorescent microsphere determinations of cerebral blood flow, calculations of cerebral oxygen consumption, and direct measurements of intracranial pressure (millimeters of mercury) were obtained at baseline (37 degrees C), before hypothermic circulatory arrest, after discontinuing circulatory arrest at 37 degrees C deep brain temperature, and at 2, 4, and 6 hours thereafter. Histopathologic features and percent brain water were determined after the animals were sacrificed. Cerebral blood flow and oxygen consumption decreased during cooling: cerebral oxygen consumption returned to baseline levels after 4 hours, but cerebral blood flow remained depressed until 6 hours in both groups. Cold reperfusion failed to improve electrophysiologic recovery or to reduce brain w...Continue Reading

References

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Citations

Jun 1, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michele Di MauroAntonio M Calafiore
Jul 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marek Ehrlich
Dec 10, 2002·Scandinavian Cardiovascular Journal : SCJ·Matti PokelaTatu Juvonen
Mar 31, 2005·The Annals of Thoracic Surgery·Christian HaglRandall B Griepp
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Axel Haverich, Christian Hagl
Sep 11, 2009·Journal of Cardiac Surgery·Gabriel AmirV Mohan Reddy
Apr 28, 2010·Artificial Organs·Xiaowei W Su, Akif Undar
Feb 21, 2013·The Journal of Thoracic and Cardiovascular Surgery·Randall B Griepp, Gabriele Di Luozzo
Apr 16, 2013·The Journal of Thoracic and Cardiovascular Surgery·Michael L JamesG Chad Hughes
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·M P EhrlichR B Griepp
Feb 1, 2005·The Annals of Thoracic Surgery·Manuel CastelláZhongtuo Tan
May 31, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Heather ReedGregory M Janelle
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Michelle L Schlunt, Stanley D Brauer
Jul 13, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·Dennis D Doblar
Mar 13, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·N KhaladjA Haverich
Jun 19, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C HaglR B Griepp
May 3, 2002·The Journal of Thoracic and Cardiovascular Surgery·Pekka RomsiTatu Juvonen

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