Cerebral embolism: local CBF and edema measured by CT scanning and Xes inhalation

Neurological Research
J S MeyerD Armstrong

Abstract

Serial CT scans were made in baboons after cerebral embolization during stable Xe inhalation for measuring local values for CBF and lambda (brain-blood partition or solubility coefficients), followed by iodine infusion for detecting blood-brain barrier (BBB) damage. Supplementary 133Xe CBF measurements were made at corresponding intervals. Persistent zones of zero flow surrounded by reduced flow were measured predominantly in subcortical regions, which showed gross and microscopic evidence of infarction at necropsy. Overlying cortex was relatively spared. Reduced lambda values attributed to edema appeared within 3--5 minutes and progressed up to 60 minutes. Damage to BBB with visible transvascular seepage of iodine began to appear 1--1 1/2 hours after embolism. In chronic animals, lambda values were persistently reduced in areas showing histologic infarction. Contralateral hemispheric CBF increased for the first 15 minutes after embolism, followed by progressive reduction after 30 minutes (diaschisis).

References

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Citations

Nov 1, 1984·Stroke; a Journal of Cerebral Circulation·Y KitagawaR L Rogers
Jul 1, 1981·Stroke; a Journal of Cerebral Circulation·J S MeyerY Harati
Jul 1, 1991·Stroke; a Journal of Cerebral Circulation·R J Andrews
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·S Mirzai, M Samii
Dec 8, 2000·Stroke; a Journal of Cerebral Circulation·J HuangE S Connolly
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TerayamaS Weathers
May 1, 1983·Stroke; a Journal of Cerebral Circulation·H SegawaM Ohta
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·J S MeyerJ Rose
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·J S MeyerT Okabe

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