PMID: 3725199Jun 6, 1986

Cerebral endothelial GABA-T activity: effects of in vivo GABA-T inhibition

Neuroscience Letters
A Krantis

Abstract

The effects of gamma-aminobutyric acid transaminase (GABA-T) inhibitors on rat endothelial GABA-T activity has been studied utilizing a modified tetrazolium salt histochemical technique. Blue-diformazan staining of cerebrovascular and parenchymal sites of GABA catabolism in normal brain was almost completely prevented in unfixed frozen brain sections from rats subjected to 'in vivo' GABA-T inhibition using aminooxyacetic acid or gabaculine. These results provide histochemical evidence for the efficacy of using systemically administered GABA-T inhibitors to inhibit endothelial GABA-T activity.

References

Dec 7, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masahiro IrifuneMichio Kawahara

Citations

Jul 1, 1971·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K L SimsF E Bloom
Apr 1, 1968·Journal of Neurochemistry·A WaksmanE Roberts
Jan 1, 1969·Biochemical Pharmacology·R H Roth, N J Giarman
Aug 1, 1983·The Journal of Comparative Neurology·T NagaiE G McGeer
Feb 1, 1980·Neuropharmacology·H H Frey, W Löscher
Dec 1, 1958·Journal of Neurochemistry·N M VAN GELDER, K A ELLIOTT
Jul 1, 1959·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H ZIMMERMANN, A G PEARSE
Mar 1, 1961·Journal of Neurochemistry·R KUTTNERM W GORDON

Related Concepts

Blood - Brain Barrier Anatomy
Aminooxyacetic Acid
Tetrazolium Salts
Blood Vessel
August Rats
Brain
Abat
Transaminases
Metabolic Inhibition
Cerebral Hemisphere Structure (Body Structure)

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