Cerebral energy metabolism and microdialysis in neurocritical care.

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Carl-Henrik Nordström

Abstract

It is of obvious clinical importance to monitor cerebral metabolism--in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and lactate), to indicate excessive interstitial levels of excitatory transmitter substance (glutamate) and to give indications of degradation of cellular membranes (glycerol). Furthermore, pharmokinetic studies can be conducted using microdialysis. This article discusses technical and physiological aspects of microdialysis, and its clinical applications in brain injury.

References

Oct 1, 1991·Journal of Internal Medicine·U Ungerstedt
Jan 1, 1987·Acta Neuropathologica·H Benveniste, N H Diemer
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R G BlasbergC S Patlak
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·L HilleredL Persson
Jul 7, 2000·Journal of Neurosurgery·P J HutchinsonJ D Pickard
Feb 26, 2004·Acta Anaesthesiologica Scandinavica·K TunbladC-H Nordström
Mar 18, 2004·British Journal of Clinical Pharmacology·Per EderothMargareta Hammarlund-Udenaes
Mar 31, 2005·Journal of Neurosurgery·Martin EngströmCarl-Henrik Nordström

❮ Previous
Next ❯

Citations

Jan 1, 2013·Acta neurochirurgica·Sebastiaan M BossersSaskia M Peerdeman
Sep 23, 2014·Clinical Neurology and Neurosurgery·Claudia DitzJan Gliemroth
Jul 30, 2014·Journal of Neuroscience Methods·Emmanuel EugèneRichard Miles
Nov 3, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A DienelCarl-Henrik Nordström
Oct 16, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Angela Sánchez-GuerreroJuan Sahuquillo
Sep 11, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A Dienel
Sep 30, 2015·Journal of Neurosurgical Anesthesiology·Claudia DitzJan Gliemroth
Mar 1, 2019·Medical Sciences : Open Access Journal·Reto A Stocker
Jan 23, 2016·Intensive Care Medicine Experimental·Rasmus JakobsenCarl-Henrik Nordström
Sep 28, 2013·Neurocritical Care·Marcelo de Lima OliveiraEdson Bor-Seng-Shu
Dec 20, 2018·Physiological Reviews·Gerald A Dienel
Jan 14, 2017·International Journal of Molecular Sciences·Cesar ReisJohn H Zhang
Jun 4, 2011·Neurocritical Care·Troels Halfeld NielsenCarl-Henrik Nordström

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

© 2022 Meta ULC. All rights reserved