Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
A ThiyagarajanAlan Winston

Abstract

Neurocognitive impairment (NCI) remains prevalent in HIV-infected subjects despite effective combination antiretroviral therapy (CART). In subjects without evidence of hepatic decompensation, NCI is also a feature of chronic HCV infection. The present study aimed to examine cerebral function and establish differences between HIV-HCV co-infected (HCVco) and HIV mono-infected (HIVmo) individuals. Neurologically asymptomatic subjects with chronic HCVco were eligible and underwent computerized neurocognitive testing (CogState; CogState Ltd, Melbourne, Australia), a dementia assessment [International HIV Dementia Scale (IHDS)] and memory assessment [the Prospective and Retrospective Memory Questionnaire (PRMQ)]. Historic control data were available for 45 HIVmo individuals and differences between study groups were assessed. Twenty-seven HCVco subjects were recruited. Plasma HIV RNA was <50 copies/mL in 25/27 of HCVco subjects and all HIVmo subjects and nadir CD4+ cell count (mean ± SD) was 214 ± 166 cells/μL and 180 ± 130 cells/μL, in HCVco and HIVmo subjects, respectively. No statistically significant differences in neurocognitive parameters or PRMQ scores were observed between groups. However, a trend towards poorer executive func...Continue Reading

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Citations

Dec 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·UNKNOWN UK Collaborative HIV Cohort (CHIC) Study Steering CommitteeCaroline A Sabin
May 7, 2013·PloS One·Alan WinstonUNKNOWN PIVOT Trial Team
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Sep 27, 2015·Journal of Neurovirology·Qing MaUNKNOWN CHARTER Group
Oct 7, 2018·Journal of Neurovirology·Ameer AbutalebEleanor Wilson
Feb 23, 2018·Infectious Diseases·Luminita Ene

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