PMID: 9437771Jan 23, 1998Paper

Cerebral glucose metabolism in childhood onset schizophrenia

Psychiatry Research
L K JacobsenA J Zametkin

Abstract

Decreased frontal cortical glucose metabolism has been demonstrated in adult schizophrenics both at rest and while engaging in tasks that normally increase frontal metabolism, such as the Continuous Performance Test (CPT). The authors tested the hypothesis that adolescents with childhood onset schizophrenia would also demonstrate hypofrontality while performing the CPT. Cerebral glucose metabolism was examined in 16 adolescents (mean age 14.1 +/- 1.7) with onset of schizophrenia by age 12 (mean age at onset 9.9 +/- 1.8) and 26 healthy adolescents selected to be similar in age, sex and handedness using positron emission tomography and 18F-fluorodeoxyglucose. Patients with childhood onset schizophrenia made fewer correct and more incorrect identifications on the CPT. Region of interest analysis revealed no significant group differences in global cerebral glucose metabolism, but increased metabolic rate in supramarginal gyrus (F = 6.74, P < 0.05) and inferior frontal gyrus/insula (F = 7.09, P < 0.05) and decreased metabolic rate in middle frontal gyrus (F = 6.72, P < 0.05) and superior frontal gyrus (t = 2.04, P < 0.05) in schizophrenics. Comparison of effect sizes with an identically designed study of adult schizophrenics did not...Continue Reading

References

Sep 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·W H GreenM Bassiri
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jan 1, 1990·Annual Review of Neuroscience·M I Posner, S E Petersen
Nov 15, 1990·The New England Journal of Medicine·A J ZametkinR M Cohen
Jan 1, 1985·Schizophrenia Bulletin·T J Crow
Jun 1, 1988·Archives of General Psychiatry·H SzechtmanJ M Cleghorn
Apr 1, 1988·Psychiatry Research·S M ResnickM Reivich
Dec 1, 1987·Acta Psychiatrica Scandinavica·F A WieselS Stone-Elander
Jan 1, 1986·The American Journal of Psychiatry·H ChabrolP Moron
Dec 1, 1984·Archives of General Psychiatry·M S BuchsbaumJ Morihisa
May 31, 1995·Psychiatry Research·J L SteinbergR R Gregory
Oct 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·J Alaghband-RadJ L Rapoport
May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·S E Chua, P J McKenna
Jan 1, 1994·Schizophrenia Bulletin·A T Russell
Jan 1, 1994·Schizophrenia Bulletin·C T GordonK E Albus
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·K P EbmeierG M Goodwin
Jan 1, 1996·Neuron·J A Fiez
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·N C AndreasenR D Hichwa
Oct 23, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·M ErnstA J Zametkin

❮ Previous
Next ❯

Citations

Dec 21, 2000·Current Psychiatry Reports·J L Rapoport, G Inoff-Germain
Dec 21, 2000·Current Psychiatry Reports·M Ernst, J M Rumsey
Oct 28, 1999·Biological Psychiatry·B VitielloK Hoagwood
Apr 9, 2001·General Hospital Psychiatry·M L Lu, I J Yeh
Mar 17, 2000·Brain Research. Brain Research Reviews·W E Bunney, B G Bunney
Mar 17, 2000·Brain Research. Brain Research Reviews·R NicolsonJ L Rapoport
May 10, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R B SilbersteinP Harris
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·P M ThompsonJ L Rapoport
Oct 1, 2006·Indian Journal of Psychiatry·Savita MalhotraMehak Kapoor
Apr 18, 1997·Psychiatry Research·J A FrazierJ L Rapoport
Oct 15, 2014·Human Genetics·Vanessa F GonçalvesJames L Kennedy
Jan 31, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S KumraR Augustin
Dec 3, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P BubberJ P Blass

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Child and Adolescent Psychiatry
J M McClellanA DuBose
Journal of the American Academy of Child and Adolescent Psychiatry
H GutgesellK A Taubert
Journal of the American Academy of Child and Adolescent Psychiatry
M CampbellG M Simpson
Journal of the American Academy of Child and Adolescent Psychiatry
R S Diler, A Avci
© 2021 Meta ULC. All rights reserved