Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans

European Journal of Clinical Investigation
M G BischofM Roden

Abstract

The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypoglycaemia-associated autonomic failure. Type 1 diabetic patients (T1DM) and healthy volunteers (CON) were studied before, during and after a hypoglycaemic (50 mg dL(-1)) hyperinsulinaemic (1.5 mU kg(-1) min(-1)) clamp test. The (1)H magnetic resonance spectroscopy of the occipital lobe of the brain was performed employing the STEAM localization technique. The water signal was suppressed by the modified SWAMP method. All spectra were acquired on a 3 Tesla scanner (80 cm MEDSPEC-DBX, Bruker Medical, Ettlingen, Germany) using a 10-cm diameter surface coil. During hypoglycaemia, T1DM showed blunted endocrine counterregulation. At baseline the brain tissue glucose : creatine ratio was lower in CON than in T1DM (CON 0.13 +/- 0.05 vs. T1DM 0.19 0.11; P < 0.01). During hypoglycaemia glucose : creatine ratios decreased in both groups (CON 0.07 +/- 0.08, P < 0.05; T1DM 0.03 +/- 0.03, P < 0.001). A significant drop in the glutamate : c...Continue Reading

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Citations

Nov 2, 2015·Cellular and Molecular Life Sciences : CMLS·Hanne M M RooijackersBastiaan E de Galan
Feb 20, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Melissa TerpstraGülin Öz
Feb 14, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Silvia MangiaIvan Tkáč
Mar 22, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hongxia LeiBernard Thorens
Jul 16, 2008·Current Diabetes Reports·Angelika Lettner, Michael Roden
Sep 6, 2007·American Journal of Physiology. Endocrinology and Metabolism·D WeghuberM G Bischof
Jan 29, 2019·Endocrine Reviews·Sarah StanleyElizabeth R Seaquist
Oct 23, 2019·The Journal of Clinical Endocrinology and Metabolism·Petr BednaříkAmir Moheet
Sep 14, 2011·Nature Reviews. Endocrinology·Julia SzendroediMichael Roden
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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