Cerebral glycogenolysis and glycolysis in malathion-treated hyperglycaemic animals

Biochemical Pharmacology
M A Matin, K Husain

Abstract

Treatment with malathion resulted in an increase in the level of blood glucose and lactate and reduced cerebral glycogen, 2 hr after its administration. The blood pyruvate level was not changed. The activities of glycogenolytic enzymes (glycogen phosphorylase and phosphoglucomutase) were increased significantly in the brain, whereas that of glucose-6-phosphatase remained unchanged. The activity of the glycolytic enzyme-hexokinase was increased significantly in malathion-treated animals, whereas those of the glucose-6-phosphate and lactate dehydrogenases were not significantly changed. The changes in enzyme activities may be a compensatory mechanism to provide energy in the form of glucose to cerebral tissue on account of stimulatory effects in malathion-treated animals.

References

Apr 17, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·K Swaminathan
Apr 10, 2012·Chemico-biological Interactions·Michael D CostaCristina W Nogueira
Aug 14, 2012·Journal of Applied Toxicology : JAT·Syed M NurulainErnest Adeghate
Dec 14, 2017·Environmental Science and Pollution Research International·Marco Antonio Ramirez-VargasMa Elena Moreno-Godinez

Related Concepts

Brain
Animal Diseases
HK1
Lactates
PGM1
Glycolysis
Glycogen
Pyruvates
Metazoa
Hyperglycemia, Postprandial

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