PMID: 2499269Apr 1, 1989Paper

Cerebral haemodynamic effects of changes in positive end expiratory pressure in preterm infants

Archives of Disease in Childhood
D B ShortlandM I Levene

Abstract

The effects of changes in positive end expiratory pressure (PEEP) on cerebral blood flow velocity, arterial blood gases, and mean arterial pressure were studied in newborn infants. In mechanically ventilated premature infants with severe respiratory disease, an increase in PEEP from 2 to 6 cm H2O was associated with an increase in cerebral blood flow velocity. There was no significant change in mean arterial blood pressure. There was a significant increase in PaO2 and PaCO2 for every stepwise rise in PEEP. Multivariate regression analysis showed that 72% of the effect on cerebral blood flow velocity was attributable to PaCO2 alone and that any change in blood pressure was not likely to contribute to these changes. There was no evidence that changes in PEEP within the commonly used range adversely affected the neonatal cardiovascular or cerebral circulations.

References

Jan 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J S HusebyJ Butler
Sep 1, 1976·Anesthesiology·S J AidinisH M Shapiro
Oct 1, 1988·Archives of Disease in Childhood·S NiijimaD H Evans
Sep 1, 1966·Anesthesiology·B C MorganW G Guntheroth
Dec 1, 1984·Archives of Disease in Childhood·D FieldI E Hopkin
Mar 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F A LeahyH Rigatto
Feb 12, 1981·The New England Journal of Medicine·F JardinJ P Bourdarias
Jun 1, 1982·Archives of Disease in Childhood·M I LeveneR F Lamont

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Citations

Jan 30, 1995·Early Human Development·R A MullaartL A Kollée
Mar 5, 2003·Paediatric Respiratory Reviews·Shelley Monkman, Haresh Kirpalani
Apr 27, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Koert A de WaalMartin Kluckow
Jul 1, 1990·Archives of Disease in Childhood·A C FentonM I Levene
Dec 24, 2013·The Journal of Pediatrics·Kiran Kumar BalegarChad C Andersen

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