PMID: 8959535Nov 1, 1996Paper

Cerebral haemorrhage complicating adult-onset Still's disease: a case report

The Journal of International Medical Research
H KurabayashiT Shirakura

Abstract

The case of a 75-year-old Japanese woman with adult-onset Still's disease who presented with cerebral haemorrhage is described. She had been in clinical remission for 2 years, after induction therapy including non-steroidal anti-inflammatory drugs, prednisolone, cyclophosphamide and mizoribine followed by auranofin, until her cerebral haemorrhage occurred, although her serum level of ferritin had gradually increased. After the onset of cerebral haemorrhage, the patient's serum level of thrombomodulin was elevated although c-reactive protein and lactate dehydrogenase were not increased. Anti-cardiolipin antibody and lupus anti-coagulant were not detected. Patients with adult-onset Still's disease are rarely reported to develop cerebral vascular disease, possibly because the disease is most frequent in young adults. The cerebral haemorrhage may have been caused by the vasculitis due to Still's disease.

References

Jan 1, 1988·Clinical Neurology and Neurosurgery·A K GururajS P Chuah
Mar 1, 1971·Annals of the Rheumatic Diseases·E G Bywaters
Mar 1, 1994·Clinical Rheumatology·K TamuraT Shirakura

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Citations

Mar 24, 2009·Rheumatology International·Hiroyuki MoritaAshio Yoshimura
Apr 21, 2021·BMC Rheumatology·Arash MollaeianChristopher J Haas

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