Cerebral haemorrhage in long-term survivors of childhood acute lymphoblastic leukaemia

European Journal of Pediatrics
T HumplP Gutjahr

Abstract

Modern treatment of childhood acute lymphoblastic leukaemia (ALL) has dramatically improved the prognosis for children with this disease. Therapeutic approaches consist of multimodal chemotherapy and radiotherapy with significant long-term side-effects. We report on 4 children out of a group of 120 newly diagnosed patients with ALL, who survived the disease for more than 2 years and developed a cerebral haemorrhage after chemotherapy and fractionated cranial irradiation. Following a period of 2-12 years the four children presented with acute neurological signs and symptoms. i.e. seizures, ataxia and hemiparesis. CT and MRI revealed intracerebral mass lesions, interpreted as haemorrhage. After neurosurgery the patients neurological state improved. Histological examination confirmed the suspected diagnosis of bleeding cavernous haemangioma or capillary telangiectases. There are two possibilities to explain these rare alterations: they may be pre-existent to the disease and therapy or they may be caused by irradiation. CONCLUSION Acute neurological symptoms in patients treated for ALL may be caused by spontaneous cerebral haemorrhaging of cavernous haemangiomas or capillary telangiectases induced by chemotherapy and/or radiotherapy.

Citations

Apr 12, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Daniel L KeeneEnrique Ventureyra
Oct 17, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandro ConsalesArmando Cama
Sep 1, 2006·Wiener medizinische Wochenschrift·Annemarie Schratter-Sehn
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·A C PaulinoB C Wen
Oct 6, 2001·Pediatric Neurology·N L Antunes
Jan 27, 2005·Journal of Paediatrics and Child Health·R Hameed, M R Zacharin
Sep 25, 2008·Neurologia Medico-chirurgica·Hiroaki MotegiYoshinobu Iwasaki
Mar 13, 2008·Neurocirugía·J F Martínez-LageM T Herrero
Jun 18, 2011·Epilepsy Research·Ramshekhar N MenonAshalatha Radhakrishnan
Feb 19, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Fumiyuki YamasakiKaoru Kurisu
Jun 22, 2016·International Journal of Radiation Oncology, Biology, Physics·Irma W E M van DijkLeontien C M Kremer
Oct 4, 2016·Journal of Neuropathology and Experimental Neurology·B K Kleinschmidt-DeMasters, Kevin O Lillehei
Apr 30, 2010·Pediatric Hematology and Oncology·Ketan P KulkarniLaxman Singh Arya
Jul 26, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sarah ElitzurShlomit Shalitin
Feb 12, 2014·Journal of Neuro-oncology·Angela Di GiannataleMaria Luisa Garrè
Jun 19, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mark Robert Keezer, Rolando Del Maestro

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