Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation

Wilderness & Environmental Medicine
Matthew R SanbornDaniel S Martin

Abstract

Alterations in cerebral blood flow (CBF) and cerebral oxygenation are implicated in altitude-associated diseases. We assessed the dynamic changes in CBF and peripheral and cerebral oxygenation engendered by ascent to altitude with partial acclimatization and hyperventilation using a combination of near-infrared spectroscopy, transcranial Doppler ultrasound, and diffuse correlation spectroscopy. Peripheral (Spo2) and cerebral (Scto2) oxygenation, end-tidal carbon dioxide (ETCO2), and cerebral hemodynamics were studied in 12 subjects using transcranial Doppler and diffuse correlation spectroscopy (DCS) at 75 m and then 2 days and 7 days after ascending to 4559 m above sea level. After obtaining baseline measurements, subjects hyperventilated to reduce baseline ETCO2 by 50%, and a further set of measurements were obtained. Cerebral oxygenation and peripheral oxygenation showed a divergent response, with cerebral oxygenation decreasing at day 2 and decreasing further at day 7 at altitude, whereas peripheral oxygenation decreased on day 2 before partially rebounding on day 7. Cerebral oxygenation decreased after hyperventilation at sea level (Scto2 from 68.8% to 63.5%; P<.001), increased after hyperventilation after 2 days at altitu...Continue Reading

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Citations

Dec 26, 2015·International Journal of Environmental Research and Public Health·Chun GuoZhitao Sun
Oct 17, 2019·High Altitude Medicine & Biology·Nicole ParrLucy Alice Hawkes
Nov 15, 2019·High Altitude Medicine & Biology·Sven KühnUlrich Limper
Apr 17, 2021·Ageing Research Reviews·Johannes BurtscherGrégoire P Millet
Jun 18, 2021·Vascular Health and Risk Management·Robert T MalletMartin Burtscher
Jul 29, 2021·European Journal of Applied Physiology·Masahiro HoriuchiSamuel J Oliver

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