Cerebral hemodynamics during orthostatic stress assessed by nonlinear modeling

Journal of Applied Physiology
Georgios D MitsisVasilis Z Marmarelis

Abstract

The effects of orthostatic stress, induced by lower body negative pressure (LBNP), on cerebral hemodynamics were examined in a nonlinear context. Spontaneous fluctuations of beat-to-beat mean arterial blood pressure (MABP) in the finger, mean cerebral blood flow velocity (MCBFV) in the middle cerebral artery, as well as breath-by-breath end-tidal CO2 concentration (P(ET(CO2))) were measured continuously in 10 healthy subjects under resting conditions and during graded LBNP to presyncope. A two-input nonlinear Laguerre-Volterra network model was employed to study the dynamic effects of MABP and P(ET(CO2)) changes, as well as their nonlinear interactions, on MCBFV variations in the very low (VLF; below 0.04 Hz), low (LF; 0.04-0.15 Hz), and high frequency (HF; 0.15-0.30 Hz) ranges. Dynamic cerebral autoregulation was described by the model terms corresponding to MABP, whereas cerebral vasomotor reactivity was described by the model P(ET(CO2)) terms. The nonlinear model terms reduced the output prediction normalized mean square error substantially (by 15-20%) and had a prominent effect in the VLF range, both under resting conditions and during LBNP. Whereas MABP fluctuations dominated in the HF range and played a significant role i...Continue Reading

References

Mar 1, 1978·Circulation Research·D D Heistad, M L Marcus
Oct 1, 1978·Circulation Research·M J Purves
Jan 1, 1991·Journal of Applied Physiology·B D LevineC G Blomqvist
Apr 1, 1990·Journal of Applied Physiology·P A RobbinsD J Paterson
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Jan 1, 1988·Annals of Biomedical Engineering·V Z Marmarelis
Feb 1, 1987·Acta Physiologica Scandinavica·I EllingsenL Walløe
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·R L BondarM L Riedesel
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·D W NewellH R Winn
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·F S LarsenG M Knudsen
Jul 1, 1994·The American Journal of Physiology·K H ChonN H Holstein-Rathlou
Nov 1, 1993·Annals of Biomedical Engineering·V Z Marmarelis
Jul 1, 1996·Journal of Applied Physiology·J C BuckeyC G Blomqvist
May 1, 1996·IEEE Transactions on Bio-medical Engineering·K H ChonR J Cohen
Sep 1, 1996·Journal of Applied Physiology·M J PoulinP A Robbins
Jul 1, 1997·Journal of Applied Physiology·J S Williams, T G Babb
Aug 1, 1997·Stroke; a Journal of Cerebral Circulation·R SchondorfT Wein
Sep 26, 1997·Stroke; a Journal of Cerebral Circulation·A P BlaberR Freeman
Feb 12, 1998·The American Journal of Physiology·R ZhangB D Levine
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T B KuoH H Hu
Mar 24, 1998·IEEE Transactions on Bio-medical Engineering·K H ChonV Z Marmarelis
Sep 25, 1998·Medical & Biological Engineering & Computing·R B PaneraiD H Evans
May 8, 1999·Journal of Applied Physiology·B J JianB J Yates
Sep 14, 1999·The American Journal of Physiology·R B PaneraiJ F Potter
Apr 1, 2000·IEEE Transactions on Bio-medical Engineering·R B PaneraiD H Evans
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·J M SerradorR L Bondar
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I A KermanB J Yates
Nov 22, 2001·Journal of Applied Physiology·R SchondorfW Cupples
Mar 19, 2002·Journal of the American College of Cardiology·Dan DanDavid M Gilligan
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Chester A Ray, Kevin D Monahan
Apr 19, 2002·Annals of Biomedical Engineering·G D Mitsis, V Z Marmarelis
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael R EdwardsRichard L Hughson
Oct 3, 2002·Circulation·Rong ZhangBenjamin D Levine
Feb 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael R EdwardsRichard L Hughson
Jul 8, 2003·The Journal of Physiology·Gabrielle LeMarbreBarbara J Morgan
Nov 13, 2004·IEEE Transactions on Bio-medical Engineering·Georgios D MitsisVasilis Z Marmarelis

❮ Previous
Next ❯

Citations

Apr 17, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ronney B Panerai
Jan 8, 2013·Annals of Biomedical Engineering·V Z MarmarelisR Zhang
Jun 19, 2013·Annals of Biomedical Engineering·V Z MarmarelisR Zhang
Jan 8, 2009·Neurocritical Care·Marek CzosnykaLuzius A Steiner
Feb 3, 2011·Physiological Measurement·Sunghan KimXiao Hu
Mar 28, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Ronney B Panerai
Jun 9, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Anthony J OconJulian M Stewart
Aug 30, 2008·EURASIP Journal on Advances in Signal Processing·Men-Tzung LoVera Novak
Jun 23, 2012·The Open Biomedical Engineering Journal·Vz MarmarelisR Zhang
Oct 5, 2013·Neurocritical Care·Georgios V VarsosMarek Czosnyka
Apr 5, 2014·Medical Engineering & Physics·V Z MarmarelisR Zhang
Dec 3, 2013·Medical Engineering & Physics·Kyriaki KostoglouGeorgios D Mitsis
Nov 5, 2008·Medical Engineering & Physics·T David, S Moore
Jul 20, 2007·Fundamental & Clinical Pharmacology·Jean-Luc Elghozi, Claude Julien
Sep 16, 2011·Acta Neurologica Scandinavica·A Y GurT Gurevich
Nov 5, 2013·IEEE Transactions on Bio-medical Engineering·Vasilis Z Marmarelis Rong Zhang
Nov 17, 2009·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Georgios D MitsisVasilis Z Marmarelis
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·V Z MarmarelisR Zhang
Jun 26, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Thomas RitzErica S Ayala
Sep 11, 2014·Frontiers in Physiology·Martin W-D Müller, Mareike Osterreich
Feb 6, 2013·American Journal of Hypertension·Min-Hui LiChih-Cherng Lu
Feb 21, 2009·American Journal of Hypertension·Jurgen A H R ClaassenRong Zhang
Jul 28, 2017·PloS One·Michał M PlacekMagdalena Kasprowicz
Feb 9, 2018·Journal of Applied Physiology·Shigehiko OgohManabu Shibasaki
Oct 5, 2018·The Journal of Physiology·Lonnie G PetersenBenjamin D Levine
Dec 13, 2018·Physiological Reviews·Nandu GoswamiVictor A Convertino
Nov 29, 2007·Cardiovascular Engineering·Ronney B Panerai
Jul 12, 2008·Journal of Applied Physiology·Roland D ThijsJohannes J van Lieshout
Feb 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philip N Ainslie, James Duffin
Jan 10, 2012·Physiological Measurement·Emmanuel KatsogridakisRonney B Panerai
Nov 18, 2006·Journal of Applied Physiology·Jurgen A H R ClaassenBenjamin D Levine
Aug 12, 2016·Physiological Measurement·Nikil PatelThompson G Robinson
Jan 17, 2015·Journal of Applied Physiology·Angela S M SalinetRonney B Panerai
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aniruddha DasPatrick J Drew
Mar 20, 2021·Frontiers in Physiology·Peter MukliAndras Eke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Biomedical Engineering
Tingying PengStephen J Payne
Annals of Biomedical Engineering
Georgios D Mitsis, Vasilis Z Marmarelis
IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society
Georgios D MitsisVasilis Z Marmarelis
© 2021 Meta ULC. All rights reserved