Cerebral hemoglobin and optical pathlength influence near-infrared spectroscopy measurement of cerebral oxygen saturation

Anesthesia and Analgesia
C D Kurth, B Uher

Abstract

Near-infrared spectroscopy (NIRS) is a noninvasive optical technique to monitor cerebral oxygen saturation at the bedside. Despite its applicability, NIRS has had limited clinical use because of concerns about accuracy, noted by intersubject variability in slope and intercept of the line between NIRS- and weighted-average arterial-cerebrovenous saturation (SMO2). This study evaluated transcranial optical pathlength and cerebral hemoglobin concentration as sources for this intersubject variability. Experiments were performed in an in vitro brain model and in piglets. Optical pathlength and cerebral hemoglobin concentration were measured by time-resolved spectroscopy (TRS). NIRS and TRS were recorded in the model, as perfusate blood saturation was varied (0%-100%) at several hemoglobin concentrations, and in piglets, as SMO2 was varied (15%-90%) before and after hemodilution. In the model, hemoglobin concentration significantly altered the NIRS versus blood saturation line slope and intercept, as well as optical pathlength. In piglets (before hemodilution), there was significant intersubject variability in NIRS versus SMO2 line slope (0.73-1.4) and intercept (-24 to 36) and in transcranial optical pathlength (13.4-16 cm) and cere...Continue Reading

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Citations

Nov 18, 2008·Journal of Anesthesia·Kenji Yoshitani, Yoshihiko Ohnishi
Jun 1, 2000·Journal of Inorganic Biochemistry·R A ShawH H Mantsch
Jul 17, 1999·Progress in Neurobiology·P L Madsen, N H Secher
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Mar 20, 2013·Journal of Cardiothoracic and Vascular Anesthesia·William J Vernick, Jacob T Gutsche
Jan 5, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·O RauxC Dadure
Jul 21, 2009·Experimental Physiology·Philip N Ainslie, Shigehiko Ogoh
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·T SakamotoR A Jonas
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Sep 30, 2006·Stroke; a Journal of Cerebral Circulation·Pippa G Al-Rawi, Peter J Kirkpatrick
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Dec 2, 2000·International Anesthesiology Clinics·A A Bendo, K Luba
Oct 6, 2000·Anesthesiology·H M WatzmanS C Nicolson

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