Cerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin´s Lymphoma: A Case Report and Review of the Literature

Pathogens
Raffaele NardoneJohann Sellner

Abstract

Patients with lymphoma are predisposed to infection because of the immunocompromised state related to the disease itself and as a consequence of chemo-/radiotherapy. Here, we report a case of Herpes-simplex virus encephalitis (HSE) in an immunosuppressed patient with splenic marginal zone lymphoma (SMZL), a rare indolent variant of non-Hodgkin´s lymphoma (NHL). The course was complicated febrile neutropenia and HSV-1-related cerebral vasculitis causing progressive ischemic stroke. This case illustrates the expanding spectrum of atypical clinical and radiological manifestations of HSE in patients treated with myelotoxic drugs. Moreover, we summarize the few central nervous system manifestations of SMZL reported in the literature and discuss distinct causes of neurological deterioration in patients with NHL.

References

Aug 3, 2002·Leukemia & Lymphoma·Vladimir GotlibAsha Nayak
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HollenderH Holte
Aug 18, 2005·International Journal of Hematology·Jordi BrunaFrancisco Rubio
Oct 31, 2006·Leukemia & Lymphoma·Amanda WedgwoodJorge E Romaguera
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nils H ThoennissenWolfgang E Berdel
May 5, 2010·Annals of Hematology·Soley BayraktarIzidore S Lossos
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Olajumoke FadugbaNina Wagner-Johnston
Nov 10, 2011·Critical Care Medicine·Nurith J JakobBrigitte Wildemann
Nov 29, 2011·The Journal of Infection·T SolomonUNKNOWN National Encephalitis Guidelines Development and Stakeholder Groups
Oct 19, 2012·American Journal of Therapeutics·Ambili Ramachandran, Robin Klein
Aug 12, 2014·Neurology. Clinical Practice·Arun Venkatesan, Romergryko G Geocadin
Nov 17, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Derek WeyckerGary H Lyman
Dec 23, 2015·Expert Review of Neurotherapeutics·Francisco Javier Carod Artal
Feb 24, 2016·Journal of Neuro-oncology·Carlos Kamiya-MatsuokaMonica E Loghin
Apr 24, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael J Bradshaw, Arun Venkatesan
Dec 7, 2016·Multiple Sclerosis and Related Disorders·Shalom HaggiagCarmela Pinnetti
Mar 16, 2017·Best Practice & Research. Clinical Haematology·Miguel A PirisManuela Mollejo
Mar 28, 2017·Médecine et maladies infectieuses·A BoucherA Mailles
Apr 12, 2017·Expert Review of Hematology·Manli JiangAndrew L Feldman
Apr 25, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Siraya JaijakulRodrigo Hasbun
May 19, 2017·Journal of Neurology·S ModiP Mitsias
Jun 2, 2017·The American Journal of Case Reports·Xiaoning GaoQuanshun Wang
Jun 5, 2017·Revista brasileira de hematologia e hemoterapia·Tayse Silva Dos SantosDanielle Leão Cordeiro de Farias
Dec 19, 2017·Journal of the Neurological Sciences·Matthias KarraschAlbrecht Kunze
Jun 19, 2018·Ecancermedicalscience·Kai SunSai Ravi Pingali
May 18, 2019·Drug Discovery Today·Paulus Stefan Rommer, Johann Sellner
Jul 30, 2019·Frontiers in Immunology·Paulus S RommerOlaf Stuve
Aug 31, 2019·Journal of Neurovirology·Vittorio ManteroAndrea Salmaggi
Sep 21, 2019·Clinical Neuroradiology·Stefan WeidauerElke Hattingen
Oct 11, 2019·Viral Immunology·Iram AminMuhammad Idrees

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
biopsy

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Related Papers

Medicina oral : órgano oficial de la Sociedad Española de Medicina Oral y de la Academia Iberoamericana de Patología y Medicina Bucal
M. CampsY. Jimenez
Ugeskrift for laeger
Konstantinos Dimopoulos, Michael Pedersen
© 2021 Meta ULC. All rights reserved