Abstract
Cerebral atrophy has been detected in patients with Parkinson's disease (PD) both with and without dementia, however differentiation based on genetic status has thus far not yielded robust findings. We assessed cortical thickness and subcortical volumes in a cohort of PD patients and healthy controls carriers of the G2019S mutation in the LRRK2 gene and the common GBA mutations, in an attempt to determine whether genetic status influences structural indexes. Cortical thickness and subcortical volumes were computed and compared between six groups of participants; idiopathic PD, GBA-PD, LRRK2-PD, non-manifesting non-carriers (NMNC), GBA-non-manifesting carriers (NMC) and LRRK2-NMC utilizing the FreeSurfer software program. All participants were cognitively intact based on a computerized cognitive assessment battery. Fifty-seven idiopathic PD patients, 9 LRRK2-PD, 12 GBA-PD, 49 NMNC, 41 LRRK2-NMC and 14 GBA-NMC participated in this study. Lower volumes among patients with PD compared to unaffected participants were detected in bilateral hippocampus, nucleus accumbens, caudate, thalamus, putamen and amygdala and the right pallidum (p = 0.016). PD patients demonstrated lower cortical thickness indexes in a majority of regions assess...Continue Reading
References
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Feb 5, 1999·NeuroImage·A M DaleM I Sereno
Jan 27, 2006·The New England Journal of Medicine·Laurie J OzeliusSusan B Bressman
Mar 15, 2006·NeuroImage·Rahul S DesikanRonald J Killiany
Apr 25, 2008·Neurology·Z Gan-OrA Orr-Urtreger
Sep 30, 2008·Journal of Neurology·Naroa Ibarretxe-BilbaoCarme Junqué
Mar 17, 2009·Brain : a Journal of Neurology·Juliane NeumannNicholas W Wood
Sep 17, 2009·Journal of Neural Transmission·Avner ThalerNir Giladi
Jan 29, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Chul Hyoung LyooMyung Sik Lee
May 4, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Liana G ApostolovaPaul M Thompson
Jun 16, 2010·NeuroImage·Christophe DestrieuxEric Halgren
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Sep 8, 2011·Human Brain Mapping·Joana Braga PereiraEduardo Tolosa
Oct 13, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Kathrin BrockmannThomas Gasser
Aug 24, 2012·Neurology·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Jan 30, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish consortium
Mar 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Mojtaba ZareiMaria Jose Martí
Jul 19, 2013·Human Brain Mapping·Ricarda A L MenkeMichele Hu
Oct 15, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Anat MirelmanUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Nov 19, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Roy N AlcalayKaren S Marder
Feb 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Apr 8, 2014·Parkinsonism & Related Disorders·Hye Mi LeeJi Hyun Kim
Aug 2, 2014·Human Brain Mapping·Katja KoelkebeckToshiya Murai
Aug 2, 2014·AJNR. American Journal of Neuroradiology·E MakN Kandiah
Dec 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanGlenn T Stebbins
Dec 30, 2014·Neurology·Rick C HelmichUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Apr 21, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Carme UribeCarme Junque
Sep 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Dolores VilasUNKNOWN the Barcelona LRRK2 Study Group
Citations
Feb 23, 2019·Human Brain Mapping·Yael JacobAvner Thaler
May 7, 2020·Frontiers in Aging Neuroscience·Micol AvenaliSilvia Cerri
Jan 26, 2021·Journal of Parkinson's Disease·Mine SezginMurat Emre
Dec 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Magdalena MroczekWadid Sirry
Jul 13, 2021·Frontiers in Neurology·Elisa Menozzi, Anthony H V Schapira
Jul 24, 2021·Journal of Neurology·Michela LeocadiFederica Agosta
Aug 24, 2021·Parkinsonism & Related Disorders·Ioanna PachiLeonidas Stefanis