Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson's Disease and Their First-Degree Unaffected Relatives

Brain Topography
Avner ThalerAnat Mirelman

Abstract

Cerebral atrophy has been detected in patients with Parkinson's disease (PD) both with and without dementia, however differentiation based on genetic status has thus far not yielded robust findings. We assessed cortical thickness and subcortical volumes in a cohort of PD patients and healthy controls carriers of the G2019S mutation in the LRRK2 gene and the common GBA mutations, in an attempt to determine whether genetic status influences structural indexes. Cortical thickness and subcortical volumes were computed and compared between six groups of participants; idiopathic PD, GBA-PD, LRRK2-PD, non-manifesting non-carriers (NMNC), GBA-non-manifesting carriers (NMC) and LRRK2-NMC utilizing the FreeSurfer software program. All participants were cognitively intact based on a computerized cognitive assessment battery. Fifty-seven idiopathic PD patients, 9 LRRK2-PD, 12 GBA-PD, 49 NMNC, 41 LRRK2-NMC and 14 GBA-NMC participated in this study. Lower volumes among patients with PD compared to unaffected participants were detected in bilateral hippocampus, nucleus accumbens, caudate, thalamus, putamen and amygdala and the right pallidum (p = 0.016). PD patients demonstrated lower cortical thickness indexes in a majority of regions assess...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jan 27, 2006·The New England Journal of Medicine·Laurie J OzeliusSusan B Bressman
Sep 30, 2008·Journal of Neurology·Naroa Ibarretxe-BilbaoCarme Junqué
Mar 17, 2009·Brain : a Journal of Neurology·Juliane NeumannNicholas W Wood
Sep 17, 2009·Journal of Neural Transmission·Avner ThalerNir Giladi
Jan 29, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Chul Hyoung LyooMyung Sik Lee
May 4, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Liana G ApostolovaPaul M Thompson
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Oct 13, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Kathrin BrockmannThomas Gasser
Aug 24, 2012·Neurology·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Jan 30, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish consortium
Mar 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Mojtaba ZareiMaria Jose Martí
Oct 15, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Anat MirelmanUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Nov 19, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Roy N AlcalayKaren S Marder
Feb 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Apr 8, 2014·Parkinsonism & Related Disorders·Hye Mi LeeJi Hyun Kim
Dec 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanGlenn T Stebbins
Dec 30, 2014·Neurology·Rick C HelmichUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Apr 21, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Carme UribeCarme Junque
Sep 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Dolores VilasUNKNOWN the Barcelona LRRK2 Study Group

❮ Previous
Next ❯

Citations

May 7, 2020·Frontiers in Aging Neuroscience·Micol AvenaliSilvia Cerri
Jan 26, 2021·Journal of Parkinson's Disease·Mine SezginMurat Emre
Dec 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Magdalena MroczekWadid Sirry
Aug 24, 2021·Parkinsonism & Related Disorders·Ioanna PachiLeonidas Stefanis

❮ Previous
Next ❯

Methods Mentioned

BETA
MDS

Software Mentioned

FreeSurfer

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

Brain Structure & Function
Noa BregmanLRRK2 Ashkenazi Jewish consortium
Movement Disorders : Official Journal of the Movement Disorder Society
Dolores Vilasthe Barcelona LRRK2 Study Group
© 2022 Meta ULC. All rights reserved