Cerebral impairment in chronic solvent-induced encephalopathy

Annals of Neurology
Ieke VisserGerard J Den Heeten

Abstract

Worldwide, many workers experience occupational exposure to organic solvents, which may induce chronic solvent-induced encephalopathy (CSE). Disturbances within the frontostriatothalamic (FST) circuitry might explain the symptomatology of CSE. We tested the hypothesis of FST circuitry abnormalities in CSE, as well as associations with performance of psychomotor speed, attention, and solvent exposure. To detect preclinical, solvent-related effects, we also studied the FST circuitry in solvent-exposed, but asymptomatic workers. Ten CSE patients, 10 asymptomatic but solvent-exposed house painters (EC), and 11 nonexposed asymptomatic carpenters were included. Dopamine D(2) receptor (D2R) binding, central nervous system tissue metabolites, and fractional anisotropy were measured within the FST circuitry, using single-photon emission computed tomography, magnetic resonance spectroscopy, and diffusion tensor imaging. Performance of psychomotor speed and attention, and severity of solvent exposure were assessed. Striatal D2R binding was reduced in CSE. In the solvent-exposed asymptomatic patients, striatal D2R binding and levels of N-acetylaspartate + N-acetylaspartyl-glutamate in frontal gray matter were reduced. In both exposed group...Continue Reading

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Citations

Jan 9, 2009·The New England Journal of Medicine·Daniel J CostelloPavan K Auluck
Jul 8, 2010·Dementia and Geriatric Cognitive Disorders·C BerrM Goldberg
Aug 25, 2009·Neurotoxicity Research·L GodderisM K Viaene
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Jun 27, 2018·International Archives of Occupational and Environmental Health·Evelien van ValenMirjam Sprangers
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology

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