Cerebral infarction after fractionated stereotactic radiation therapy of benign anterior skull base tumors

Clinical and Translational Radiation Oncology
Arnar AstradssonMarianne Juhler

Abstract

The purpose of this study was to examine the occurrence of cerebral infarction (ischemic stroke), in a large combined cohort of patients with anterior skull base meningiomas, pituitary adenomas and craniopharyngiomas, after fractionated stereotactic radiation therapy (FSRT). All patients, 18 years and older, with anterior skull base meningiomas, pituitary adenomas and craniopharyngiomas, treated with fractionated stereotactic radiation, in our center, from January 1999 to December 2015 were identified. In total 169 patients were included. The prescription dose to the tumor was 54 Gy for 164 patients (97%) and 46.0-52.2 Gy for 5 patients (3%). Cases of cerebral infarctions subsequent to FSRT were identified from the Danish National Patient Registry and verified with review of case notes. The rate of cerebral infarction after FSRT was compared to the rate in the general population with a one sample t-test after standardization for age and year. We explored if age, sex, disease type, radiation dose and dose per fraction was associated with increased risk of cerebral infarction using univariate Cox models. At a median follow-up of 9.3 years (range 0.1-16.5), 7 of the 169 patients (4.1%) developed a cerebral infarction, at a median ...Continue Reading

Citations

Aug 3, 2021·Frontiers in Oncology·Svenja BoekhoffHermann L Müller

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Methods Mentioned

BETA
irradiating

Software Mentioned

R
Varian Eclipse
LINAC
BrainLab
SPSS
BrainScan

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