Cerebral ischemia induces angiogenesis in the peri-infarct regions via Notch1 signaling activation

Experimental Neurology
Changhong RenKunlin Jin

Abstract

The Notch1 signaling pathway is considered as one of important regulators of angiogenesis during development, but its role in cerebral ischemia-induced angiogenesis is less well understood. Here, we used human and rodent brains to explore whether Notch1 signaling was involved in the angiogenesis after focal cerebral ischemia. Using immunohistochemistry on surgically resected ischemic stroke brain tissue, we found that the area, volume, and length of the blood vessels in the peri-infarct regions were significantly increased after ischemic stroke in humans, compared with non-ischemic stroke specimens. In addition, the expression of the activated form of Notch1 (Notch intracellular domain; NICD) was increased in endothelial cells of the peri-infarct region. The Notch1 ligand, Jagged1, also increased in abundance in the peri-infarct regions in human. We further confirmed that Notch1 signaling was activated in the peri-infarct regions in a mouse distal middle cerebral artery occlusion (dMCAO) model. Lentivirus-mediated Notch1 knockdown reduced ischemia-induced angiogenesis in the peri-infarct regions of the brain. Our findings suggest that ischemic stroke in human can also induce angiogenesis in the peri-infarct regions as does in a...Continue Reading

Citations

Aug 10, 2018·Aging and Disease·Changhong RenXunming Ji
Mar 7, 2019·Journal of Molecular Neuroscience : MN·Yingfang TianYong Liu
Jun 26, 2020·Neurological Research·Changhong RenYuchuan Ding
Jun 26, 2021·Neurotoxicity Research·Sedigheh EskandariGholamreza Bahrami

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