Cerebral lesions on 7 tesla MRI in patients with sickle cell anemia

Cerebrovascular Diseases
Veronica van der LandPaul J Nederkoorn

Abstract

Patients with sickle cell anemia (SCA) are at a high risk to develop cerebral damage. Most common are silent cerebral infarctions (SCIs), visible as white matter hyperintensities (WMHs) on MRI in a patient without neurological deficits. The etiology of SCIs remains largely unclear. In addition, patients are at an increased risk for overt stroke, which is associated with large vessel disease. This classification based on the presence or absence of neurological deficits may not be the most fitting for research purposes, as it does not match the different underlying pathology. A classification based on imaging findings may therefore be a more straightforward approach for research purposes. We explored the feasibility to identify imaging features of SCIs in young, asymptomatic patients with SCA using ultra high-field 7 Tesla (7T) MRI. 7T MRI has a high resolution, which offers a unique chance to investigate small subclinical brain lesions in detail. To explore the superiority of 7T in identifying imaging abnormalities, we compared our results with 3T MRI. Ten young, neurologically asymptomatic patients with SCA underwent 7T and 3T MRI; 10 healthy, age-matched controls underwent 7T MRI. We used existing neuroimaging standards to cla...Continue Reading

Citations

Jan 14, 2016·Blood·Michael R DeBaun, Fenella J Kirkham
Oct 18, 2018·Annual Review of Pathology·Prithu SunddEnrico M Novelli
Jan 11, 2020·American Journal of Hematology·Lena VáclavůBart J Biemond
Apr 8, 2016·Current Opinion in Hematology·Gregory J Kato
May 1, 2020·British Journal of Haematology·Raffaella Colombatti, Biree Andemariam
Sep 3, 2019·Frontiers in Neurology·Hanne StotesburyFenella J Kirkham
Feb 23, 2021·Expert Review of Hematology·Hanne StotesburyFenella Jane Kirkham

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