Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1

Pflügers Archiv : European journal of physiology
Simone WärntgesFlorian Lang

Abstract

The serum- and glucocorticoid-dependent kinase SGK1 is regulated by alterations of cell volume, whereby cell shrinkage increases and cell swelling decreases the transcription, expression and activity of SGK1. The kinase is expressed in all human tissues studied including the brain. The present study was performed to localize the sites of SGK1 transcription in the brain, to elucidate the influence of the hydration status on SGK1 transcription and to explore the functional significance of altered SGK1 expression. Northern blot analysis of human brain showed SGK1 to be expressed in all cerebral structures examined: amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, subthalamic nucleus and thalamus. In situ hybridization and immunohistochemistry in the rat revealed increased expression of SGK1 in neurons of the hippocampal area CA3 after dehydration, compared with similar slices from brains of euvolaemic rats. Additionally, several oligodendrocytes, a few microglial cells, but no astrocytes, were positive for SGK1. The abundance of SGK1 mRNA in the temporal lobe, including hippocampus, was increased by dehydration and SGK1 transcription in neuroblastoma cells was stimulated by an increase of extracellular os...Continue Reading

Citations

Jun 15, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Aug 10, 2006·Pflügers Archiv : European journal of physiology·Rexhep RexhepajFlorian Lang
Sep 1, 2012·The British Journal of Nutrition·Erica PerrierIvan Tack
Jan 28, 2005·The European Journal of Neuroscience·Christine C StichelHermann Lübbert
Feb 8, 2006·Annual Review of Physiology·Johannes LoffingOlivier Staub
Aug 6, 2010·American Journal of Physiology. Cell Physiology·Irina M ZemtsovaFlorian Lang
Apr 30, 2010·American Journal of Physiology. Renal Physiology·Rolando Carrisoza-GaytánLaura I Escobar
Dec 25, 2004·Physiological Reviews·Steven C HebertWenhui Wang
Apr 7, 2011·Experimental & Molecular Medicine·Chang Hoon Cho
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jianchao XuGary V Desir
Nov 1, 2011·Clinical and Experimental Nephrology·Florian Lang, Volker Vallon
Mar 19, 2005·The Journal of Physiology·Nathalie Strutz-SeebohmFlorian Lang
Oct 27, 2015·Frontiers in Cellular Neuroscience·Veronika MatschkeNathalie Strutz-Seebohm
Feb 1, 2013·Neuropathology and Applied Neurobiology·P SahinA H Hainsworth
Oct 27, 2004·Biochemical and Biophysical Research Communications·Christoph BöhmerFlorian Lang
Feb 18, 2006·Biochemical Pharmacology·Sabine C WolfBernhard R Brehm
Jun 6, 2003·Biochemical and Biophysical Research Communications·Christoph BoehmerF Lang
Oct 26, 2005·Behavioural Brain Research·Undine E LangFlorian Lang
Aug 30, 2005·Molecular and Cellular Neurosciences·Bodo SchoenebeckChristine C Stichel
Jun 14, 2005·Expert Opinion on Therapeutic Targets·Gary V Desir
Jul 28, 2016·Biochemical and Biophysical Research Communications·Koichi InoueTakatoshi Ueki
Mar 2, 2005·Biochemical and Biophysical Research Communications·Christoph BoehmerFlorian Lang
Oct 22, 2002·Expert Opinion on Therapeutic Targets·Hans O Kalkman
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Cai TangFlorian Lang
May 9, 2007·Phytotherapy Research : PTR·Risa SakaiKenji Watanabe
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ekaterina ShumilinaFlorian Lang
Oct 25, 2006·Stress : the International Journal on the Biology of Stress·Neeltje G van GemertMarian Joëls
Jan 5, 2007·American Journal of Physiology. Cell Physiology·Emily CordasGéza Fejes-Tóth
Mar 14, 2003·Pflügers Archiv : European journal of physiology·Hamdy M EmbarkFlorian Lang
Oct 12, 2010·American Journal of Physiology. Cell Physiology·Leonid TyanFlorian Lang
Jan 26, 2005·Biochemical Society Transactions·F LangC Böhmer
Sep 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Florian Lang, Ekaterina Shumilina
Dec 21, 2018·Frontiers in Cellular Neuroscience·Sun-Hwa Lee, Kyoungho Suk

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