Cerebral maturation in the early preterm period-A magnetization transfer and diffusion tensor imaging study using voxel-based analysis

NeuroImage
Revital Nossin-ManorJohn G Sled

Abstract

The magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) correlates of early brain development were examined in cohort of 18 very preterm neonates (27-31 gestational weeks) presenting with normal radiological findings scanned within 2weeks after birth (28-32 gestational weeks). A combination of non-linear image registration, tissue segmentation, and voxel-wise regression was used to map the age dependent changes in MTR and DTI-derived parameters in 3D across the brain based on the cross-sectional in vivo preterm data. The regression coefficient maps obtained differed between brain regions and between the different quantitative MRI indices. Significant linear increases as well as decreases in MTR and DTI-derived parameters were observed throughout the preterm brain. In particular, the lamination pattern in the cerebral wall was evident on parametric and regression coefficient maps. The frontal white matter area (subplate and intermediate zone) demonstrated a linear decrease in MTR. While the intermediate zone showed an unexpected decrease in fractional anisotropy (FA) with age, with this decrease (and the increase in mean diffusivity (MD)) driven primarily by an increase in radial diffusivity (RD) values, the su...Continue Reading

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Citations

Nov 29, 2015·Seminars in Ultrasound, CT, and MR·András JakabDaniela Prayer
Apr 28, 2016·Brain Research·Maya WeinsteinDafna Ben Bashat
Apr 2, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Eva BültmannHeinrich Lanfermann
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Sep 14, 2018·F1000Research·Diliana PechevaSerena J Counsell
Dec 21, 2016·Brain Plasticity·Jessica DuboisGhislaine Dehaene-Lambertz
Dec 24, 2018·NeuroImage. Clinical·Marlee M VandewouwJohn G Sled
Nov 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Beomgu KangHye-Young Heo

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