Cerebral Metabolic Changes During Sleep

Current Neurology and Neuroscience Reports
Nadia Nielsen AallingMauro DiNuzzo

Abstract

The goal of the present paper is to review current literature supporting the occurrence of fundamental changes in brain energy metabolism during the transition from wakefulness to sleep. Latest research in the field indicates that glucose utilization and the concentrations of several brain metabolites consistently change across the sleep-wake cycle. Lactate, a product of glycolysis that is involved in synaptic plasticity, has emerged as a good biomarker of brain state. Sleep-induced changes in cerebral metabolite levels result from a shift in oxidative metabolism, which alters the reliance of brain metabolism upon carbohydrates. We found wide support for the notion that brain energetics is state dependent. In particular, fatty acids and ketone bodies partly replace glucose as cerebral energy source during sleep. This mechanism plausibly accounts for increases in biosynthetic pathways and functional alterations in neuronal activity associated with sleep. A better account of brain energy metabolism during sleep might help elucidate the long mysterious restorative effects of sleep for the whole organism.

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Citations

Aug 20, 2019·Alzheimer's Research & Therapy·Jeffrey CummingsLeung-Wing Chu
May 23, 2019·Frontiers in Cellular Neuroscience·Jong M RhoCarl E Stafstrom
Oct 21, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V M Kovalzon, Yu V Panchin
Nov 17, 2020·Frontiers in Neurology·Zhaoyu WangFatemeh Haghighi
Feb 12, 2021·Molecular Brain·Iyo KoyanagiMasanori Sakaguchi
Feb 16, 2021·Brain Structure & Function·John H HarknessBarbara A Sorg
Dec 17, 2020·Seminars in Cell & Developmental Biology·Aksu GunayP Hande Ozdinler
Jun 22, 2021·Journal of Sleep Research·Isaac AlmendrosTarja Saaresranta
Jul 24, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Theodosia VallianatouDaniel Globisch
Sep 10, 2021·Scientific Reports·Simeng ZhangKumpei Tokuyama

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