Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study

Diabetologia
G J BiesselsK Nicolay

Abstract

It is increasingly evident that the brain is another site of diabetic end-organ damage. The pathogenesis has not been fully explained, but seems to involve an interplay between aberrant glucose metabolism and vascular changes. Vascular changes, such as deficits in cerebral blood flow, could compromise cerebral energy metabolism. We therefore examined cerebral metabolism in streptozotocin-diabetic rats in vivo by means of localised 31P and 1H magnetic resonance spectroscopy. Rats were examined 2 weeks and 4 and 8 months after diabetes induction. A non-diabetic group was examined at baseline and after 8 months. In 31P spectra the phosphocreatine:ATP, phosphocreatine:inorganic phosphate and ATP:inorganic phosphate ratios and intracellular pH in diabetic rats were similar to controls at all time points. In 1H spectra a lactate resonance was detected as frequently in controls as in diabetic rats. Compared with baseline and 8-month controls 1H spectra did, however, show a statistically significant decrease in N-acetylaspartate:total creatine (-14% and -23%) and N-acetylaspartate:choline (-21% and -17%) ratios after 2 weeks and 8 months of diabetes, respectively. No statistically significant alterations in cerebral energy metabolism w...Continue Reading

Citations

Oct 3, 2013·Brain Research Bulletin·Ana StančićBato Korać
Jun 21, 2014·Cell Biochemistry and Function·Nicéia Spanholi CalgarotoMaria Rosa Chitolina Schetinger
Jun 23, 2009·Pediatric Diabetes·Elisabeth A Northam, Ashleigh Lin
Jun 4, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hui ZhangHao Lei
Apr 20, 2012·Journal of Diabetes and Its Complications·Ercan OzsoyPenpe Gul Firat
Jul 18, 2014·Endocrinology and Metabolism·Junghyun H LeeIn Kyoon Lyoo
Dec 29, 2013·Molecular and Cellular Biochemistry·Naiara StefanelloMaria Rosa Chitolina Schetinger

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