Cerebral metabolism of patients with stenosis of the internal carotid artery before and after endarterectomy

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
J van der GrondW P Mali

Abstract

Occlusion or severe stenosis, with a reduction in the diameter of more than 70% of the extracranial arteries may lead to hpoperfusion of the brain with an increased risk of cerebral infarction. The aim of this study was to investigate whether endarterectomy of stenosed internal carotid arteries leads to alternations in cerebral metabolism in regions in which no infarcts were visible with magnetic resonance imaging (MRI). We studied 10 healthy control subjects and 20 patients with transient or nondisabling cerebral ischemia with MRI and 1H magnetic resonance spectroscopic imaging. All patients underwent carotid endarterectomy. Patients were examined 1 week before and 3-6 months after carotid endarterectomy. The N-acetyl aspartate (NAA)/choline ratio in the symptomatic hemisphere before endarterectomy (2.29 +/- 0.42) was significantly (p < 0.001) lower than for control subjects (3.18 +/- 0.32). In five of the patients lactate was detected preoperatively in regions that were not infarcted. The NAA/choline ratio in the symptomatic hemisphere of these five patients did not increase significantly after endarterectomy (1.99 +/- 0.22 vs. 2.23 +/- 0.48). The NAA/choline ratio in patients without lactate preoperatively increased signific...Continue Reading

References

Feb 1, 1977·Archives of Neurology·R E Myers, S Yamaguchi
Jul 1, 1992·Neurology·C C FordG A Rosenberg
Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L H ChangP R Weinstein
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J W HuggM W Weiner
Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·G D GrahamJ W Prichard
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K R WagnerR E Myers
Jun 1, 1992·Radiology·J H DuijnM W Weiner
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·S R FelberF Gerstenbrand
Oct 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D L RothmanJ W Prichard
Oct 1, 1991·Stroke; a Journal of Cerebral Circulation·Y XuT L James
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M ChoppK M Welch
Mar 1, 1990·Stroke; a Journal of Cerebral Circulation·M ChoppK M Welch
Jun 1, 1990·Stroke; a Journal of Cerebral Circulation·D J CombsC Smith
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M SendaF S Buonanno
Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H BruhnR Sauter
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·D L Birken, W H Oldendorf
Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A GoldmanF Plum
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
Aug 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R P KraigW A Pulsinelli
Apr 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M N Gould
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A SyrotaJ C Baron
Dec 1, 1973·Archives of Neurology·K A Hossmann, P Kleihues
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M GardinerB K Siesjö
Nov 1, 1980·Stroke; a Journal of Cerebral Circulation·K A Hossmann, F J Schuier
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S RehncronaB K Siesjö
Feb 1, 1995·Stroke; a Journal of Cerebral Circulation·G D GrahamJ W Prichard
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·H JørgensenT S Olsen
May 1, 1994·Stroke; a Journal of Cerebral Circulation·P GideonO Henriksen
Sep 1, 1993·Stroke; a Journal of Cerebral Circulation·K HoukinT Kashiwaba

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Citations

Feb 25, 2005·Journal of Neurology·M J E van ZandvoortE H F de Haan
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·D W KangK H Chang
Jan 23, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Claudia Roberta de AndradeAna Maria de Oliveira
Jan 10, 2013·Neurorehabilitation and Neural Repair·Sorin C CraciunasCarmen M Cirstea
Mar 31, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·V Zbornikova, L Skoglund
Oct 28, 1997·Stroke; a Journal of Cerebral Circulation·C J KlijnJ van Gijn
Nov 1, 1996·Stroke; a Journal of Cerebral Circulation·J van der GrondW P Mali
Jan 4, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K J van EverdingenJ van der Grond

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