Dec 11, 2013

Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study

Alzheimer Disease and Associated Disorders
Saima HilalNarayanaswamy Venketasubramanian

Abstract

Cerebral microbleeds (CMBs) are considered to be a novel marker of cerebral small vessel disease. However, the link with cognitive impairment remains unclear. We investigated whether CMBs-independent of other traditional markers of cerebral small vessel disease-are related to cognition. Chinese subjects from the population-based Singapore Chinese Eye Study, who failed an initial cognitive screening and were recruited into the ongoing Epidemiology of Dementia in Singapore Study, underwent neuropsychological testing and 3 T brain magnetic resonance imaging. The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images. Other magnetic resonance imaging lesions that were graded included presence of lacunes, white matter lesion, and total brain volumes. A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores. Among 282 subjects, 91 had any CMBs (32.3%), of whom 36 (12.8%) had multiple CMBs. CMBs were-independent of cardiovascular risk factors and other markers of cerebral small vessel disease-significantly associated with poorer cognitive function as reflected by composite Z-score (mean difference...Continue Reading

  • References4
  • Citations28

References

  • References4
  • Citations28

Citations

Mentioned in this Paper

Magnetic Resonance Imaging
Brain
Memory for Designs Test
Executive Function
Cardiovascular Diseases
Cerebral Hemorrhage
Cerebral Hemisphere Structure (Body Structure)
Mild Cognitive Disorder
Cerebral Small Vessel Diseases
Epidemiology

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.