Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study

Lancet Neurology
Duncan WilsonCROMIS-2 collaborators

Abstract

Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that are prone to intracranial bleeding. We aimed to determine whether presence of cerebral microbleeds can identify patients at high risk of symptomatic intracranial haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient ischaemic attack. Our observational, multicentre, prospective inception cohort study recruited adults aged 18 years or older from 79 hospitals in the UK and one in the Netherlands with atrial fibrillation and recent acute ischaemic stroke or transient ischaemic attack, treated with a vitamin K antagonist or direct oral anticoagulant, and followed up for 24 months using general practitioner and patient postal questionnaires, telephone interviews, hospital visits, and National Health Service digital data on hospital admissions or death. We excluded patients if they could not undergo MRI, had a definite contraindication to anticoagulation, or had previously received therapeutic anticoagulation. The primary outcome was symptomatic intracranial haemorrhage occurring at any time before the final follow-up at 24 months. The log-rank test was used to compare rates of intracranial ha...Continue Reading

Associated Clinical Trials

Citations

Sep 14, 2018·Current Cardiology Reports·Rocco J Cannistraro, James F Meschia
Feb 15, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Joji B Kuramatsu, Hagen B Huttner
Apr 14, 2019·Annals of Neurology·David J SeiffgeUNKNOWN CROMIS-2, RAF, RAF-DOAC, SAMURAI, NOACISP LONGTERM, Erlangen and Verona registry collaborators
Dec 17, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Yannie SooUNKNOWN IPAAC study group
Mar 4, 2019·Practical Neurology·Jonathan Gordon BestDavid John Werring
Jun 13, 2019·Expert Review of Neurotherapeutics·Isabel C HostettlerDavid J Werring
Jun 21, 2019·Current Neurology and Neuroscience Reports·Solene Moulin, Charlotte Cordonnier
Feb 13, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Maud PétraultVincent Bérézowski
Dec 10, 2019·Stroke; a Journal of Cerebral Circulation·So-Ryoung LeeGregory Y H Lip
Apr 21, 2019·Neurology·Joan Martí-FàbregasUNKNOWN HERO study investigators
May 31, 2019·Neurology·Rocco J CannistraroJames F Meschia
May 31, 2019·Journal of Neurointerventional Surgery·William K DiproseP Alan Barber
Feb 14, 2020·Annals of Neurology·David J SeiffgeUNKNOWN RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, and Verona registry collaborators
Mar 25, 2019·F1000Research·Ravi Garg, José Biller
Dec 17, 2019·Current Treatment Options in Cardiovascular Medicine·Daniel C Brooks, Joseph L Schindler
Dec 12, 2019·Current Treatment Options in Cardiovascular Medicine·Christian E CajavilcaRajan R Gadhia
Feb 6, 2020·Journal of Neurology·Muneaki KikunoUNKNOWN CHALLENGE ESUS/C.S. collaborators
Nov 23, 2019·Stroke; a Journal of Cerebral Circulation·Marco Pasi, Charlotte Cordonnier
Oct 7, 2018·Journal of Neurology·Xiaodong ChenZhengqi Lu
May 9, 2019·Current Treatment Options in Neurology·Tiberiu A PanaPhyo K Myint
Mar 9, 2019·Journal of Neurology·Gargi BanerjeeUNKNOWN CROMIS-2 collaborators
Mar 4, 2020·Der Nervenarzt·S Knecht, T Schmidt-Wilcke
Aug 14, 2019·Annals of Clinical and Translational Neurology·Vasileios-Arsenios LioutasGeorgios Tsivgoulis
Dec 17, 2018·Translational Stroke Research·Ashfaq ShuaibRichard Camicioli
Nov 23, 2019·Stroke; a Journal of Cerebral Circulation·M Edip GurolLouise D McCullough
Oct 9, 2020·Stroke; a Journal of Cerebral Circulation·Kang-Ho ChoiKi-Hyun Cho
Sep 17, 2020·Neurology·Jonathan G BestUNKNOWN Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators
Oct 20, 2020·JAMA Neurology·Laurent Puy, Charlotte Cordonnier
Dec 1, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Mariel G KozbergSusanne J van Veluw
Dec 8, 2020·Stroke; a Journal of Cerebral Circulation·Houwei DuUNKNOWN Clinical Relevance of Microbleeds in Stroke (CROMIS-2) Collaborators
Sep 12, 2020·Neurology·Maria J KnolUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02513316

Software Mentioned

ROCKET

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Related Papers

International Journal of Stroke : Official Journal of the International Stroke Society
Andreas CharidimouDavid J Werring
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E R SpeltenM A G Sprangers
© 2022 Meta ULC. All rights reserved