Cerebral Microcirculation during Experimental Normovolaemic Anemia

Frontiers in Neurology
Judith BellapartJohn F Fraser

Abstract

Anemia is accepted among critically ill patients as an alternative to elective blood transfusion. This practice has been extrapolated to head injury patients with only one study comparing the effects of mild anemia on neurological outcome. There are no studies quantifying microcirculation during anemia. Experimental studies suggest that anemia leads to cerebral hypoxia and increased rates of infarction, but the lack of clinical equipoise, when testing the cerebral effects of transfusion among critically injured patients, supports the need of experimental studies. The aim of this study was to quantify cerebral microcirculation and the potential presence of axonal damage in an experimental model exposed to normovolaemic anemia, with the intention of describing possible limitations within management practices in critically ill patients. Under non-recovered anesthesia, six Merino sheep were instrumented using an intracardiac transeptal catheter to inject coded microspheres into the left atrium to ensure systemic and non-chaotic distribution. Cytometric analyses quantified cerebral microcirculation at specific regions of the brain. Amyloid precursor protein staining was used as an indicator of axonal damage. Animals were exposed to ...Continue Reading

References

Jan 1, 1976·Annual Review of Physiology·A G Kovách, P Sándor
Jun 1, 1988·Journal of Neurochemistry·S E EmotoD D Gilboe
Mar 1, 1987·The Journal of Trauma·J B FortuneD M Shah
Jan 1, 1995·Cardiovascular Research·J P HakkinenD R Knight
Sep 29, 1998·Critical Care Medicine·Alex ValadkaClaudia S Robertson
Mar 23, 2000·Cardiovascular Research·F W Prinzen, J B Bassingthwaighte
Aug 17, 2000·Intensive Care Medicine·S M PeerdemanW P Vandertop
Jun 26, 2001·Clinical and Laboratory Haematology·D S SilverbergM Blum
Jun 21, 2002·Transfusion Medicine Reviews·Jeffrey L CarsonDavid Henry
Oct 19, 2002·Current Opinion in Critical Care·Andrew J Johnston, Arun K Gupta
May 1, 2004·Critical Care Medicine·Patricia C Y Liaw
Nov 4, 2005·Journal of Neurosurgery·Michael F StiefelAnthony Marmarou
Jun 9, 2007·Journal of Applied Physiology·Gregory M T HareAndrew J Baker
Feb 21, 2009·Neurological Research·Tatsuki ItohHiroyuki Ito
Jun 17, 2011·The Journal of Physiology·Philip N Ainslie, Kurt J Smith
Jul 4, 2012·Annals of Internal Medicine·Jeffrey L CarsonClinical Transfusion Medicine Committee of the AABB
Aug 28, 2012·The Journal of Trauma and Acute Care Surgery·Judith BellapartJohn F Fraser
Sep 3, 2013·Vox Sanguinis·G SimonovaY L Fung
Dec 18, 2013·The American Journal of Medicine·Shelley R SalpeterSaurav Chatterjee
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Claudia S RobertsonPaul Swank

Citations

Nov 10, 2018·Intensive Care Medicine Experimental·Judith BellapartJohn F Fraser

Methods Mentioned

BETA
dissection
Blood
Flow Cytometric
flow cytometry

Related Concepts

Anemia
Anesthesia Procedures
Blood Transfusion
Brain
Craniocerebral Trauma
Heart
Infarction
Microcirculation
Microspheres
Regression Analysis

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.