PMID: 6172952Aug 1, 1981Paper

Cerebral microembolization in the rat: changes in blood-brain barrier permeability and cerebral blood flow as related to the degree of ischemia

Acta Neurologica Scandinavica
A BeleyJ E Hardebo

Abstract

Unilateral cerebral microembolism was performed in the rat by injecting calibrated, 50 micrometers in diameter, carbonized microspheres into the internal carotid artery. The events that follow brain ischemia due to cerebral embolization were studied by the analysis of the blood-brain barrier (BBB) function, the degree of regional cerebral blood flow (CBF) and the development of brain edema. Two hours after embolization there was no change in the brain water content. The local CBF (14C-ethanol technique) was only reduced in the ipsilateral hemisphere. Twenty-four hours after embolization the brain water content was increased significantly in the ipsilateral, but not in the contralateral hemisphere. Local CBF further decreased in the ipsilateral hemisphere and a reduction in flow was also observed in the contralateral hemisphere. Embolization led to an increase in the BBB permeability, analysed as regional penetrability of 3H-dextran and of Evans blue-albumin complexes, which was restricted to the side of the injection of the microspheres.

References

Jan 1, 1975·Archives of Neurology·K KogureO M Reinmuth
Jan 1, 1979·Stroke; a Journal of Cerebral Circulation·A M BraletJ Bralet
May 1, 1978·Archives of Neurology·F J SchuierK J Zülch
Apr 1, 1978·Journal of Neurochemistry·R GaudetT P Wang
Feb 1, 1978·Annals of Neurology·K M WelchE Chabi
Nov 1, 1977·Archives of Neurology·W M ViseK J Zülch
Jan 1, 1972·Archives of Neurology·B A SiegelE J Potchen
Dec 15, 1958·Acta Physiologica Scandinavica·A BERTLERE ROSENGREN
Oct 1, 1959·Journal of Neuropathology and Experimental Neurology·A T STEEGMANN, J DE LA FUENTE
Jan 1, 1962·Journal of Neuropathology and Experimental Neurology·J S MEYER TAZAKIY

❮ Previous
Next ❯

Citations

Nov 1, 1984·Acta Neurologica Scandinavica·J E Hardebo, A Beley
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·A D Perez-TrepichioS C Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.