Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?

Stroke and Vascular Neurology
Luke DixonBrynmor Jones

Abstract

Cerebral microhaemorrhages are increasingly being recognised as a complication of COVID-19. This observational retrospective study aims to further investigate the potential pathophysiology through assessing the pattern of microhaemorrhage and clinical characteristics of patients with COVID-19 and microhaemorrhage. By comparing with similar patterns of microhaemorrhage in other non-COVID-19 disease, this study aims to propose possible common pathogenic mechanisms. A retrospective observational case series was performed identifying all patients with COVID-19 complicated by cerebral microhaemorrhage on MRI. The distribution and number of microhaemorrhages were recorded using the microbleed anatomical scale, and patients' baseline characteristics and salient test results were also recorded. Cerebral microhaemorrhages were noted to have a predilection for the corpus callosum, the juxtacortical white matter and brainstem. All patients had a preceding period of critical illness with respiratory failure and severe hypoxia necessitating intubation and mechanical ventilation. This study demonstrates a pattern of cerebral microhaemorrhage that is similar to the pattern reported in patients with non-COVID-19 related critical illness and ot...Continue Reading

References

Oct 23, 2002·Brain : a Journal of Neurology·Heike J SchochHugo H Marti
Jul 30, 2004·Brain : a Journal of Neurology·David J WerringH Rolf Jäger
Feb 14, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·S SveinbjornsdottirL J Launer
Jan 24, 2009·Lancet Neurology·Mark H WilsonChris H Imray
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Mariëlle M F PoelsMonique M B Breteler
Feb 28, 2013·Annals of Neurology·Mark H WilsonUNKNOWN Birmingham Medical Research Expeditionary Society and Caudwell Xtreme Everest Research Group
May 18, 2016·Nucleic Acids Research·Sasha BabickiDavid S Wishart
Aug 20, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jennifer ChangJavier M Romero
Feb 7, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jay StarkeyToshio Moritani
Feb 27, 2017·Stroke; a Journal of Cerebral Circulation·Evgenia M FanouDaniel M Mandell
Jan 27, 2019·AJNR. American Journal of Neuroradiology·P H HackettK B Reynard
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 29, 2020·The European Respiratory Journal·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Apr 16, 2020·The New England Journal of Medicine·Julie HelmsFerhat Meziani
Apr 22, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zahra Sedaghat, Narges Karimi
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
May 15, 2020·Radiology·Jeffrey R SachsCarol P Geer
May 22, 2020·Radiology·Alireza RadmaneshGirish M Fatterpekar
May 22, 2020·The New England Journal of Medicine·Maximilian AckermannDanny Jonigk
May 23, 2020·AJNR. American Journal of Neuroradiology·A M FranceschiM Castillo
May 23, 2020·Nature Reviews. Immunology·Laure-Anne TeuwenPeter Carmeliet
May 28, 2020·Neurology. Neuroimmunology and Neuroinflammation·Luke DixonAlex Everitt
Jun 12, 2020·Brain, Behavior, and Immunity·Matthew BengerLaszlo Sztriha
Jul 22, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Afshin A DivaniMichel Torbey

❮ Previous
Next ❯

Citations

Mar 14, 2021·Neurological Research and Practice·Ummehan ErmisJörg B Schulz
Mar 27, 2021·Clinical Neuroradiology·Marjolaine UginetKarl-Olof Lovblad
Jun 3, 2021·Viruses·Maria de Fatima Viana Vasco AragaoMarcelo Moraes Valenca
Jul 8, 2021·Brain, Behavior, & Immunity Health·Pablo NajtDónal G Fortune
Jul 23, 2021·SAGE Open Medical Case Reports·Philip KeithL Keith Scott

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
sedation

Software Mentioned

Heatmapper

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.