Cerebral microvascular disease predicts renal failure in type 2 diabetes.

Journal of the American Society of Nephrology : JASN
Takashi UzuRyuichi Kikkawa

Abstract

Abnormalities in small renal vessels may increase the risk of developing impaired renal function, but methods to assess these vessels are extremely limited. We hypothesized that the presence of small vessel disease in the brain, which manifests as silent cerebral infarction (SCI), may predict the progression of kidney disease in patients with type 2 diabetes. We recruited 608 patients with type 2 diabetes without apparent cerebrovascular or cardiovascular disease or overt nephropathy and followed them for a mean of 7.5 years. At baseline, 177 of 608 patients had SCI, diagnosed by cerebral magnetic resonance imaging. The risk for the primary outcome of ESRD or death was significantly higher for patients with SCI than for patients without SCI [hazard ratio, 2.44; 95% confidence interval (CI) 1.36 to 4.38]. The risk for the secondary renal end point of any dialysis or doubling of the serum creatinine concentration was also significantly higher for patients with SCI (hazard ratio, 4.79; 95% CI 2.72 to 8.46). The estimated GFR declined more in patients with SCI than in those without SCI; however, the presence of SCI did not increase the risk for progression of albuminuria. In conclusion, independent of microalbuminuria, cerebral mic...Continue Reading

References

Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
May 16, 2000·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·M E Murphy, M E Tublin
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerMonique M B Breteler
Dec 28, 2002·Diabetes Care·Mark E MolitchUNKNOWN American Diabetes Association
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerUNKNOWN Rotterdam Scan Study
Apr 30, 2003·Diabetes Care·Aaron I VinikRoy Freeman
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Holly J KramerChi-Yuan Hsu
Sep 23, 2003·Stroke; a Journal of Cerebral Circulation·Kazuo EguchiKazuyuki Shimada
Nov 5, 2003·Journal of Hypertension·Judith A Whitworth, UNKNOWN World Health Organization, International Society of Hypertension Writing Group
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Richard J MacIsaacMark E Cooper
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shuzo KobayashiHiromichi Kumagai
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Stephen L SeligerDavid S Siscovick
Nov 18, 2005·Journal of the American Society of Nephrology : JASN·Masaomi Nangaku
Mar 29, 2006·Diabetes·Sanne M ManschotUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Apr 7, 2006·The New England Journal of Medicine·Steven M Greenberg
Jun 22, 2007·Lancet Neurology·Sarah E VermeerPeter J Koudstaal
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler
Oct 25, 2008·Diabetes Research and Clinical Practice·Shin-ichi ArakiRyuichi Kikkawa
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR

❮ Previous
Next ❯

Citations

Jul 9, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryotaro BouchiYasuhiko Iwamoto
Apr 16, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gunter WolfUlrich A Müller
Dec 15, 2010·American Journal of Nephrology·Lena M GiangMark J Sarnak
Jun 11, 2011·American Journal of Nephrology·Baris AfsarMehmet Kanbay
Jan 13, 2012·F1000 Medicine Reports·Alejandro R Chade
Jan 29, 2011·Cardiology Research and Practice·Masaki Mogi, Masatsugu Horiuchi
Jul 20, 2011·Indian Journal of Nephrology·E Ritz, X Zeng
Oct 2, 2013·Clinical and Experimental Nephrology·Miho ShimizuTakashi Wada
May 15, 2013·Current Cardiovascular Risk Reports·Ankur JindalJames R Sowers
Jan 28, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J MacisaacGeorge Jerums
Feb 23, 2013·Journal of the American Society of Hypertension : JASH·Alejandro R Chade, Nicholas Stewart
Jan 8, 2013·The Medical Clinics of North America·Eberhard Ritz
Sep 24, 2010·Kidney International·Manjula Kurella Tamura, Kristine Yaffe
Dec 27, 2011·Journal of the American Society of Hypertension : JASH·Takashi UzuRyuichi Kikkawa
Mar 15, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manjula Kurella TamuraUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Apr 28, 2012·Geriatrics & Gerontology International·Shin-ichi ArakiUNKNOWN Japanese Elderly Intervention Trial Research Group
Feb 20, 2012·Journal of Diabetes Investigation·Keiko NakaoHiroshi Maegawa
Aug 26, 2015·European Radiology·Robert C BertheauChristopher L Schlett
Feb 4, 2011·Diabetes Research and Clinical Practice·Itsuko MiyazawaHiroshi Maegawa
Feb 26, 2015·Der Radiologe·C L SchlettS Weckbach
Jun 30, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Hideaki ShimaMasaaki Inaba
Feb 7, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·D N KoyeD J Magliano
Jul 7, 2017·European Journal of Clinical Investigation·Yu Chang YehMeng-Kun Tsai

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.