Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Neuron
Danielle K SandsmarkRamon Diaz-Arrastia

Abstract

Traumatic brain injury (TBI) is one the most common human afflictions, contributing to long-term disability in survivors. Emerging data indicate that functional improvement or deterioration can occur years after TBI. In this regard, TBI is recognized as risk factor for late-life neurodegenerative disorders. TBI encompasses a heterogeneous disease process in which diverse injury subtypes and multiple molecular mechanisms overlap. To develop precision medicine approaches where specific pathobiological processes are targeted by mechanistically appropriate therapies, techniques to identify and measure these subtypes are needed. Traumatic microvascular injury is a common but relatively understudied TBI endophenotype. In this review, we describe evidence of microvascular dysfunction in human and animal TBI, explore the role of vascular dysfunction in neurodegenerative disease, and discuss potential opportunities for vascular-directed therapies in ameliorating TBI-related neurodegeneration. We discuss the therapeutic potential of vascular-directed therapies in TBI and the use and limitations of preclinical models to explore these therapies.

References

Nov 1, 1990·Archives of Neurology·J I Engelhardt, S H Appel
Feb 6, 1971·Lancet·D I Graham, J H Adams
Feb 1, 1995·Neuropathology and Applied Neurobiology·D I GrahamG W Roberts
Oct 1, 1995·Journal of Neurotrauma·N A MartinD Hovda
Jan 17, 1996·Annals of the New York Academy of Sciences·A D RosesP T Xi
Apr 4, 2000·Neurology·Z GuoL A Farrer
Jan 5, 2002·Neurobiology of Aging·P Grammas, R Ovase
Jan 1, 2003·Journal of Neurosurgery·Sherman C SteinDouglas H Smith
Jun 17, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Alfonso Rodríguez-BaezaAngel Garnacho
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S FlemingerA Giora
Nov 19, 2003·Psychiatry Research·Omer BonneBernard Lerer
Apr 2, 2004·Topics in Magnetic Resonance Imaging : TMRI·Andrea Kassner, Timothy P L Roberts
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Jun 2, 2005·Annals of Neurology·Annemieke RuitenbergMonique M B Breteler
Feb 3, 2006·Acta Neuropathologica·Eszter FarkasPaul G M Luiten
May 30, 2006·Current Pharmaceutical Design·Niklas MarklundTracy K McIntosh
Sep 22, 2006·Journal of Alzheimer's Disease : JAD·Lakshmi ThirumangalakudiPaula Grammas
May 19, 2007·The Journal of Head Trauma Rehabilitation·Jeffrey David LewineWilliam W Orrison
Jul 17, 2008·Journal of Neurotrauma·Kathryn E SaatmanUNKNOWN Workshop Scientific Team and Advisory Panel Members
Oct 25, 2008·European Neurology·Hani T S Benamer, Donald G Grosset
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·Jennifer K LeeKen M Brady
Aug 15, 2009·Neuron·Jungsu KimDavid M Holtzman
Oct 16, 2009·Journal of Bioenergetics and Biomembranes·Cristina CarvalhoGeorge Perry
Jan 16, 2010·AJNR. American Journal of Neuroradiology·K B WalhovdUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 13, 2010·The American Journal of Pathology·Xiangling YinPaula Grammas
Apr 3, 2010·Neurobiology of Aging·Uma S YezhuvathHanzhang Lu
May 28, 2010·Journal of Neurotrauma·Brent E Masel, Douglas S DeWitt
Jun 5, 2010·CNS & Neurological Disorders Drug Targets·J C Fernández-ChecaA Colell
Jun 17, 2010·Nature Reviews. Neurology·Dan ShlosbergAlon Friedman
Jul 24, 2010·Neurocritical Care·Doris A ChatfieldDavid K Menon

❮ Previous
Next ❯

Citations

Sep 1, 2020·Acta Neuropathologica·Nils KorteDavid Attwell
Mar 7, 2020·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Sep 29, 2020·Current Neurology and Neuroscience Reports·Sara M LippaKimbra Kenney
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Margalit HaberRamon Diaz-Arrastia
Dec 9, 2020·Thrombosis Research·W Brad HubbardRolando E Rumbaut
Dec 8, 2020·Frontiers in Cellular Neuroscience·María Lacalle-AuriolesThomas M Durcan
Feb 16, 2021·Frontiers in Aging Neuroscience·Johannes BoltzeMarietta Zille
Oct 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Edwin Vázquez-RosaAndrew A Pieper
May 11, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tamara L BakerSandy R Shultz
May 17, 2021·Experimental Neurology·Zachary M WeilA Courtney DeVries
Jun 3, 2021·International Journal of Molecular Sciences·Christian StetterChristiane Albert-Weißenberger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Experimental Neurology
Kimbra KenneyRamon Diaz-Arrastia
Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal De L'Académie Canadienne De Psychiatrie De L'enfant Et De L'adolescent
Russell James SchacharMaureen Dennis
Current Translational Geriatrics and Experimental Gerontology Reports
Xianwei ZengZhenbo Hu
© 2021 Meta ULC. All rights reserved