Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone.

The Journal of Pharmacology and Experimental Therapeutics
Aisha I Kelly-CobbsAdviye Ergul

Abstract

Dysregulation of cerebral vascular function and, ultimately, cerebral blood flow (CBF) may contribute to complications such as stroke and cognitive decline in diabetes. We hypothesized that 1) diabetes-mediated neurovascular and myogenic dysfunction impairs CBF and 2) under hypoxic conditions, cerebral vessels from diabetic rats lose myogenic properties because of peroxynitrite (ONOO(-))-mediated nitration of vascular smooth muscle (VSM) actin. Functional hyperemia, the ability of blood vessels to dilate upon neuronal stimulation, and myogenic tone of isolated middle cerebral arteries (MCAs) were assessed as indices of neurovascular and myogenic function, respectively, in 10- to 12-week control and type 2 diabetic Goto-Kakizaki rats. In addition, myogenic behavior of MCAs, nitrotyrosine (NY) levels, and VSM actin content were measured under normoxic and hypoxic [oxygen glucose deprivation (OGD)] conditions with and without the ONOO(-) decomposition catalyst 5,10,15,20-tetrakis(4-sulfonatophenyl) prophyrinato iron (III), chloride (FeTPPs). The percentage of myogenic tone was higher in diabetes, and forced dilation occurred at higher pressures. Functional hyperemia was impaired. Consistent with these findings, baseline CBF was lo...Continue Reading

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Citations

Mar 13, 2014·Translational Stroke Research·Sherif HafezAdviye Ergul
Jul 8, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Mohammed AbdelsaidAdviye Ergul
Jan 22, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Aisha I Kelly-CobbsAdviye Ergul
Feb 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adviye ErgulSusan C Fagan
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Jul 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Trevor HardiganAdviye Ergul
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Aug 8, 2013·Stroke; a Journal of Cerebral Circulation·Roshini PrakashAdviye Ergul
May 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Maha CouchaAdviye Ergul
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Oct 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Maha CouchaAdviye Ergul
Sep 17, 2016·Clinical Science·Trevor HardiganAdviye Ergul
May 19, 2020·Clinical and Experimental Hypertension : CHE·Noushin YazdaniSaeid Taheri
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Jan 2, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Maha CouchaAdviye Ergul
Jun 28, 2018·Physiological Research·W LiA Ergul
Jun 15, 2019·Neuromolecular Medicine·Ladonya JacksonAdviye Ergul
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Weiguo LiAdviye Ergul
Mar 19, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gianna HuberWalter Raasch

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