PMID: 9188086May 12, 1997Paper

Cerebral noradrenaline spillover and its relation to muscle sympathetic nervous activity in healthy human subjects

Journal of the Autonomic Nervous System
G W LambertMurray D Esler

Abstract

Studies using internal jugular vein blood sampling in human subjects have demonstrated the release of noradrenaline from the brain and have provided a link between central nervous system noradrenergic neuronal activity and renal, cardiac and total body sympathetic activity. The aim of this study was to further categorise the dependence of regional sympathetic nervous function on central nervous system noradrenergic neuronal processes by combining measures of internal jugular venous noradrenaline spillover, as an indicator of brain noradrenaline release, and cerebral blood flow scans with measures of the overall integrated neuronal firing rate for the body as a whole, the spillover of noradrenaline into the coronary sinus and with measurements of resting muscle sympathetic nerve activity. Positive veno-arterial plasma noradrenaline gradients were found across the brain, with the plasma concentration being 17 +/- 3% (p < 0.01) greater in the internal jugular vein. Linear regression analysis revealed a significant relationship between the degree of muscle sympathetic nerve activity and the spillover of noradrenaline from subcortical brain regions (y = 0.1 x + 16.0; r = 0.81, p < 0.02). The rate of spillover of noradrenaline for th...Continue Reading

References

Nov 1, 1977·The Journal of Physiology·G Sundlöf, B G Wallin
Jan 1, 1978·The Journal of Physiology·G Sundlöf, B G Wallin
Aug 1, 1991·Journal of Hypertension·J Chalmers, P Pilowsky
Sep 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·I T MeredithG Eisenhofer
Jan 1, 1991·Journal of Gerontology·S IwaseF Kobayashi
Aug 1, 1990·Acta Anaesthesiologica Scandinavica·S LundinM Elam
Jan 1, 1986·Journal of Cardiovascular Pharmacology·M EslerG Hasking
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M D EslerG W Lambert
Mar 1, 1984·Brain : a Journal of Neurology·B G Wallin, L Stjernberg
Jan 1, 1981·Acta Physiologica Scandinavica·B G WallinL E Lindblad
Jun 25, 1995·Journal of the Autonomic Nervous System·V G Macefield, B G Wallin
Jun 1, 1994·Circulation·U ScherrerP Nicod
Jun 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Fagius, B G Wallin
Jan 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·N Singewald, A Philippu
Apr 1, 1993·Baillière's Clinical Endocrinology and Metabolism·C J Mathias
Mar 15, 1996·The Journal of Physiology·B G WallinM D Esler

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Citations

Sep 12, 2000·Current Hypertension Reports·G W Lambert
Jul 17, 1999·Progress in Neurobiology·P L Madsen, N H Secher
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·G W Lambert
Aug 25, 1999·Journal of Hypertension·G Grassi, M Esler
Oct 26, 2001·Journal of Hypertension·Y B SverrisdóttirM Elam
May 29, 2004·Journal of Hypertension·Margaret C S BoguszewskiYrsa Bergmann Sverrisdóttir
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·Christopher J Mathias
Mar 11, 2008·Experimental Physiology·S Kasparov, A G Teschemacher
Jan 22, 2013·Trends in Neurosciences·Stephanie E Simonds, Michael A Cowley
Jan 30, 2004·Diabetes·Douglas R Seals, Christopher Bell
Jun 10, 2010·Journal of Psychopharmacology·N J KalkA R Lingford-Hughes
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·J M SerradorR L Bondar
Oct 29, 2005·The Journal of Physiology·Gavin LambertPetre Nitescu
Jun 17, 1998·The Journal of Clinical Endocrinology and Metabolism·Y B SverrisdóttirG Johannsson
Jun 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elisabet Stener-VictorinYrsa Bergmann Sverrisdottir
Jul 4, 2019·Annals of the New York Academy of Sciences·Gavin W LambertElisabeth A Lambert
Mar 16, 2017·Frontiers in Physiology·Daniel L T ChenJerry R Greenfield

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