Cerebral ocular Whipple's disease: a 62-year odyssey from death to diagnosis

Neurology
D L KnoxD S Zee

Abstract

A 47-year-old white man with dementia, supranuclear ophthalmoplegia, and myoclonic ocular and facial jerks died in 1931. The case report in 1936 by Ford and Walsh diagnosed encephalitis. In 1993, we made a clinical diagnosis of Whipple's disease on the basis of the 1936 publication. We restudied the pathologic material and found, in addition to extensive encephalitis, PAS-positive material in only the eye, brain, spinal cord, and pituitary. Electron microscopy demonstrated free and intracytoplasmic microorganisms in the eye and brain. We review the history of cerebral ocular Whipple's disease and the implications from this case, which occurred before the development of antibiotics.

Citations

Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A H Rajput, J D McHattie
Jul 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·E PeruccaF Savoldi
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·A D SiderowfG T Liu
Jul 11, 2006·Current Infectious Disease Reports·Mara M Lugassy, Elan D Louis
Nov 1, 1996·Clinical Neurology and Neurosurgery·W I VerhagenM M Schuurmans
Dec 6, 2001·Ophthalmology·R Y ChanC S Foster
Jan 19, 1999·Gastroenterology Clinics of North America·M L Nakla, K F Heffler
Sep 5, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G D Perkin, I Murray-Lyon
Nov 21, 2000·Postgraduate Medical Journal·R N Ratnaike
May 1, 2009·Emerging Infectious Diseases·Michel DrancourtDidier Raoult
Apr 9, 2002·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Andrew G Lee
Jan 20, 2010·Survey of Ophthalmology·Ryan A ScheurerDean M Cestari
Oct 10, 2007·Clinical Neurology and Neurosurgery·Liyong WuJianping Jia
Dec 10, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·José Fidel Baizabal-CarvalloJoseph Jankovic
Jun 24, 2011·Journal of the Neurological Sciences·Wazim MohamedSunitha Santhakumar
Oct 1, 1996·Annals of Neurology·E D LouisJ Odel
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Roberta VitalianiPeter P Pramstaller
Jan 1, 2017·Expert Review of Ophthalmology·Sushant Puri, Aasef G Shaikh
Aug 3, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Meagan D SeayKathleen B Digre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

American Journal of Ophthalmology
R L LesserF H O'Brien
Brain Pathology
Thomas RobertsonJon Reimers
Acta neurologica Belgica
P De JongheC Ceuterick
Neurologia i neurochirurgia polska
M BarcikowskaP P Liberski
© 2021 Meta ULC. All rights reserved