PMID: 8942392Nov 1, 1996Paper

Cerebral oxidative metabolism in hypertension

Clinical Science
C J Dickinson

Abstract

1. The evidence is now overwhelming that so-called 'essential' hypertension in man, i.e. high systemic arterial pressure for no apparent cause, is commonly initiated by increased efferent sympathetic activity directed to the cardiovascular system. Eventually structural and other changes take place in the heart, kidneys and blood vessels. These may reinforce, augment and even conceal the initially neurogenic background. The cause of the increased sympathetic activity remains in dispute, but it is probably not psychological in most cases. 2. The brain has a high requirement for energy-twice that of the heart, at rest. In the normotensive adult, the brain's needs are met almost exclusively by the oxidation of glucose. This results in a cerebral respiratory quotient for the brain of approximately unity. The brain can utilize other materials, notably ketones, as it does to a considerable extent in the fetus. It retains this capability in adult life, even though normal adults do not make use of it. 3. In human hypertension the cerebral respiratory quotient falls in proportion to the rise of arterial pressure, indicating the consumption of other fuels in addition to glucose. beta-Hydroxybutyrate is certainly one of these, but fatty ac...Continue Reading

Citations

Aug 16, 2013·Journal of Human Hypertension·A J HogarthM H Tayebjee
Nov 7, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A R HobsonD G Thompson
Jul 13, 2006·Journal of Experimental Psychology. Animal Behavior Processes·Gonzalo P Urcelay, Ralph R Miller
Oct 6, 1997·The Medical Clinics of North America·L G Navar

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