Cerebral Oxygen Saturation in Children With Congenital Heart Disease and Chronic Hypoxemia

Anesthesia and Analgesia
Barry D KussmanDoff B McElhinney

Abstract

Increased hemoglobin (Hb) concentration accompanying hypoxemia is a compensatory response to maintain tissue oxygen delivery. Near infrared spectroscopy (NIRS) is used clinically to detect abnormalities in the balance of cerebral tissue oxygen delivery and consumption, including in children with congenital heart disease (CHD). Although NIRS-measured cerebral tissue O2 saturation (ScO2) correlates with arterial oxygen saturation (SaO2), jugular bulb O2 saturation (SjbO2), and Hb, little data exist on the interplay between these factors and cerebral O2 extraction (COE). This study investigated the associations of ScO2 and ΔSaO2-ScO2 with SaO2 and Hb and verified the normal range of ScO2 in children with CHD. Children undergoing cardiac catheterization for CHD were enrolled in a calibration and validation study of the FORE-SIGHT NIRS monitor. Two pairs of simultaneous arterial and jugular bulb samples were drawn for co-oximetry, calculation of a reference ScO2 (REF CX), and estimation of COE. Pearson correlation and linear regression were used to determine relationships between O2 saturation parameters and Hb. Data were also analyzed according to diagnostic group defined as acyanotic (SaO2 ≥ 90%) and cyanotic (SaO2 < 90%). Of 65 c...Continue Reading

References

Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Jakobsen, E Enevoldsen
Feb 1, 1971·The American Journal of Cardiology·A RosenthalA S Nadas
Jan 1, 1970·Cardiovascular Research·C G LaFarge, O S Miettinen
Mar 1, 1996·The Annals of Thoracic Surgery·P E DaubeneyS A Webber
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M OjaP C van Zijl
Mar 7, 2000·Anesthesia and Analgesia·R M Schell, D J Cole
Oct 6, 2000·Anesthesiology·H M WatzmanS C Nicolson
Jul 24, 2001·The Annals of Thoracic Surgery·C D KurthS C Nicolson
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C Dean KurthJohn McCann
Dec 2, 2004·The Journal of Thoracic and Cardiovascular Surgery·Daniel J LichtJohn A Detre
Nov 26, 2005·The Journal of Thoracic and Cardiovascular Surgery·Catherine L DentC Dean Kurth
Jan 20, 2006·Journal of Applied Physiology·Kui Xu, Joseph C Lamanna
Apr 6, 2006·Advances in Experimental Medicine and Biology·Paul B BenniBillie L Short
Apr 10, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·Gregory W Fischer
Mar 21, 2009·Anesthesia and Analgesia·C Dean KurthAndreas W Loepke
Jul 21, 2009·Experimental Physiology·Philip N Ainslie, Shigehiko Ogoh
Dec 17, 2009·British Journal of Anaesthesia·J M Murkin, M Arango
Aug 30, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Carolyn T SpencerW Todd Cade
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Clare E Elwell, Chris E Cooper
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gorm GreisenMartin Wolf
Jan 4, 2012·Journal of the American College of Cardiology·Jeffrey A FeinsteinGerard R Martin
Aug 4, 2012·The Annals of Thoracic Surgery·Renee N KreegerC Dean Kurth
Oct 30, 2012·American Journal of Respiratory and Critical Care Medicine·John B West
Sep 12, 2013·Anesthesia and Analgesia·Philip E BicklerMark D Rollins

❮ Previous
Next ❯

Citations

Jun 20, 2017·Anesthesia and Analgesia·Adam C Adler, Stephen A Stayer
Dec 28, 2019·Indian Journal of Pediatrics·Nilüfer Yalındağ ÖztürkFeyza İnceköy Girgin
Mar 21, 2019·Current Opinion in Anaesthesiology·Andrew Davidson, Justin Skowno
May 1, 2018·Frontiers in Pediatrics·Judith Ju-Ming WongJan Hau Lee
Mar 19, 2021·Neonatal Network : NN·Nhu N TranKen M Brady
Mar 27, 2021·Cardiology in the Young·William M JacksonLena S Sun
Apr 8, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazuya TeradaTakashi Kusaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.