Cerebral oxygenation and oxygen extraction in the preterm infant during desaturation: effects of increasing FiO(2) to assist recovery

Neonatology
Willem BaertsFrank van Bel

Abstract

In the clinical setting, episodes of desaturation in newborn infants are often treated by increasing the fraction of inspired oxygen (FiO(2)). To study the effect of an increase in FiO(2) on cerebral oxygenation during recovery from desaturation, as measured by near-infrared spectroscopy (NIRS). Peripheral arterial saturation (SaO(2)), NIRS-monitored cerebral saturation (rScO(2)), and fractional cerebral oxygen extraction (cFTOE) were analyzed in the first 3 days of life during 6 episodes of desaturation (SaO(2) <75%, >30 s) in each of 24 otherwise stable spontaneously breathing preterm infants (gestational age 29.8 ± 1.5 weeks, birth weight 1,215 ± 280 g; mean ± SD), during 3 episodes without and 3 episodes with increased FiO(2) during recovery from desaturation. Post-recovery SaO(2) with increased FiO(2) was significantly higher than post-recovery SaO(2) without increased FiO(2). Post-recovery SaO(2) and rScO(2) were significantly increased over baseline saturations when FiO(2) was increased. Post-recovery rScO(2) was very high for several minutes in some cases, while cFTOE was highly suggestive of oxygen delivery that exceeded consumption. Assuming that NIRS-measured rScO(2) is an indicator of cerebral oxygen content, an inc...Continue Reading

Citations

Mar 5, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Manuel B SchmidHans Fuchs
Feb 24, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Mads F BertelsenDale A Smith
Aug 20, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·H FuchsM B Schmid
Sep 1, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·D SeidelM Knüpfer
Nov 12, 2013·Journal of Internal Medicine·F Sjöberg, M Singer
Mar 15, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Stefaan H A J TytgatDavid C van der Zee
Jan 9, 2017·The Journal of Pediatrics·Rosemary S C HorneFlora Y Wong
May 19, 2018·The Journal of Physiology·Simerdeep K DhillonLaura Bennet
Jul 11, 2018·Children·Aisling A GarveyEugene M Dempsey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.