PMID: 9534672Apr 16, 1998Paper

Cerebral oxygenation during cardiopulmonary bypass

Archives of Disease in Childhood
Stephen P WardleA Michael Weindling

Abstract

Cerebral fractional oxygen extraction (FOE) was monitored in 30 children, using near infrared spectroscopy during cardiopulmonary bypass, to investigate the effect of hypothermia and circulatory arrest. One group of children (n = 15) underwent profound hypothermia with total circulatory arrest (n = 8) or continuous flow (n = 7). Another group (n = 15), of whom only one had circulatory arrest, underwent mild (n = 6) or moderate (n = 9) hypothermia. The mean FOE (SD) before bypass was 0.35 (0.12) and this correlated negatively with the preoperative arterial oxygen content (r = -0.58). Between the stage of cooling on bypass and cold bypass there was a reduction in FOE in all groups. Between cold bypass and rewarming there was an increase in FOE only in the groups with continuous flow. In the circulatory arrest group, the FOE remained low during rewarming and was significantly lower than that of the continuous flow group. No patients died and none had neurological abnormalities postoperatively. Apparent changes in oxidised cytochrome oxidase concentration were also monitored using near infrared spectroscopy. There was a fall in cytochrome aa3 on starting cardiopulmonary bypass, but there were no significant differences in the chang...Continue Reading

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Citations

Mar 12, 2010·Early Human Development·Michael Weindling, Fauzia Paize
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Jennifer C HirschJames G Gurney
Sep 5, 2006·Clinics in Perinatology·Adam J Wolfberg, Adré J du Plessis
Aug 4, 2006·Journal of Cardiothoracic and Vascular Anesthesia·George M Hoffman
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Dean B AndropoulosCharles D Fraser
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S P WardleA M Weindling
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christopher M KissackA Michael Weindling
Oct 28, 2015·The Journal of Perinatal & Neonatal Nursing·Mi-Jung Hwang, Geun Hee Seol
Oct 23, 2010·Stroke; a Journal of Cerebral Circulation·Elise A VerhagenArend F Bos
May 31, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Patrizia ZaramellaLino Chiandetti
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Mauro Arrica, Bruno Bissonnette
Jul 13, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·Harvey L EdmondsErle H Austin

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