Abstract
Near infrared spectroscopy (NIRS) shows large changes in cerebral oxyhemoglobin (Hbo2), deoxyhemoglobin (Hb), and oxidation state of cytochrome aa3 (Cyto2) in infants undergoing cardiopulmonary bypass and deep hypothermic circulatory arrest (CPB-DHCA). To evaluate the physiologic significance of these clinical NIRS measurements, we applied the technique in a piglet model of CPB-DHCA. After an initial stabilization period on CPB, animals (n = 8) were cooled to 15 degrees C, subjected to DHCA for 1 h, then reperfused with rewarming and monitored for 180 min. NIRS measurements were compared with determinations of cerebral blood flow (CBF). During cooling, Cyto2 decreased markedly, whereas Hbo2 increased. DHCA was associated with a sharp decrease in Hbo2, a corresponding increase in Hb, and a smaller, less consistent further decrease in Cyto2. NIRS measurements recovered toward baseline with reperfusion. CBF decreased during cooling and recovered to baseline levels with reperfusion. These findings are consistent with existing human data and show that 1) cooling is associated with increased oxygenation of cerebral hemoglobin despite a reduction in CBF; 2) Cyto2 becomes more reduced during cooling, consistent with a net cellular oxyg...Continue Reading
References
Dec 23, 1977·Science·F F Jöbsis
Sep 25, 1992·Biochimica Et Biophysica Acta·M WyssT Wallimann
Oct 1, 1992·Anesthesiology·C D KurthM Delivoria-Papadopoulos
Jan 1, 1992·Biology of the Neonate·T N Raju
Nov 1, 1991·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·F FarisA Spencer
Mar 29, 1991·Biochimica Et Biophysica Acta·G C BrownS Wray
Apr 1, 1991·Japanese Circulation Journal·M Tamura
Jul 1, 1991·Circulation·W J DreyerM L Entman
Jan 1, 1990·Developmental Neuroscience·J S WyattE O Reynolds
Mar 1, 1990·Journal of Applied Physiology·J S WyattE O Reynolds
Mar 30, 1988·Biochimica Et Biophysica Acta·S WrayE O Reynolds
Nov 8, 1986·Lancet·J S WyattE O Reynolds
Jan 1, 1988·Advances in Experimental Medicine and Biology·M CopeP van der Zee
Dec 1, 1988·Physics in Medicine and Biology·D T DelpyJ Wyatt
May 1, 1982·The Journal of Pediatrics·A LaptookW Oh
Jul 1, 1994·The Annals of Thoracic Surgery·M AokiD H Holtzman
Aug 1, 1995·Anesthesiology·F Dexter, B J Hindman
Apr 1, 1995·Annals of Neurology·A J du PlessisJ J Volpe
Mar 1, 1995·Pediatric Research·M TsujiD Holtzman
Jan 1, 1995·Anesthesiology·C D KurthS C Nicolson
Jul 1, 1994·Medical & Biological Engineering & Computing·M Tamura, T Tamura
Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P FallonM J Elliott
Dec 1, 1993·Journal of Neurosurgery·J I AusmanR F Ghaly
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M AokiR A Jonas
Dec 1, 1993·The Annals of Thoracic Surgery·W J GreeleyR M Ungerleider
Dec 1, 1993·The Annals of Thoracic Surgery·P FallonA D Edwards
Jul 1, 1993·Journal of Clinical Monitoring·C D KurthB Chance
Oct 7, 1993·The New England Journal of Medicine·J W NewburgerJ H Ware
May 1, 1993·The Annals of Thoracic Surgery·M AokiR A Jonas
Jan 24, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J W Dickerson, J Dobbing
Citations
Jun 9, 2005·Experimental Brain Research·Mona C ToetFrank van Bel
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Robert H HabibAamir Shah
Mar 23, 2000·Progress in Neurobiology·K Ide, N H Secher
Nov 19, 2002·Pediatric Neurology·Yoko Hoshi, Shing-Jen Chen
Mar 31, 1999·Seminars in Pediatric Neurology·R C Vannucci, J Towfighi
Jan 4, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A W GavilanesC E Blanco
Jan 28, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A W D GavilanesC E Blanco
Dec 16, 1998·Pediatric Research·L BennetM A Hanson
Jun 1, 2001·Pediatric Research·T SakamotoG Nollert
Jul 8, 2008·Journal of Biomedical Optics·Yasuyuki KakihanaMamoru Tamura
Jul 2, 2009·Journal of Biomedical Optics·Chao ZhouArjun G Yodh
May 5, 1999·The Journal of Physiology·L BennetA J Gunn
Jan 3, 2007·The Journal of Thoracic and Cardiovascular Surgery·Takashi MiuraHiromi Kurosawa
Jul 19, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Roy E GagnonJacques G Leblanc
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Ikuo HaginoRichard A Jonas
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·T SakamotoR A Jonas
Dec 23, 2016·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert H ThieleZhiyi Zuo
Mar 10, 2017·Anesthesia and Analgesia·Robert H Thiele
May 29, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maria ErecinskaIan A Silver
Aug 17, 2011·Perfusion·C S ParkY L Kim
Apr 5, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·Sujata ChakravartiAlexander J C Mittnacht
Nov 8, 2008·Stroke; a Journal of Cerebral Circulation·Rebecca L SherlockUNKNOWN aCCENT
Mar 17, 2019·Journal of Biomedical Optics·Thu Nga NguyenSteve Lin
Jun 20, 2018·Anesthesia and Analgesia·Robert H ThieleZhiyi Zuo
Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S AshrafK Watterson
Jun 26, 2001·Acta Anaesthesiologica Scandinavica·H Abdul-KhaliqP E Lange
Dec 1, 1998·Physics in Medicine and Biology·E L HullT H Foster
Jun 9, 2005·Metabolic Brain Disease·Roy E GagnonJacques G LeBlanc
Jun 25, 2021·Applied Ergonomics·Kiana KiaJeong Ho Kim