Cerebral Oxygenation, Superior Vena Cava Flow, Severe Intraventricular Hemorrhage and Mortality in 60 Very Low Birth Weight Infants

Neonatology
Rosa Maria CerboMauro Stronati

Abstract

Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous cerebral tissue oxygen saturation (rSO2), superior vena cava flow (SVCf) and cerebral fractional oxygen extraction (CFOE) in very low birth weight (VLBW) infants during the first 48 h of life. We studied a prospective cohort of 60 VLBW infants admitted to our neonatal intensive care unit within the first 6 h of life between March 2010 and June 2012. rSO2 (expressed as a number of summary measures) was continuously monitored with near-infrared spectroscopy (INVOS 5100 Somanetic) during the first 48 h of life, SCVf was measured at 4-6, 12, 24 and 48 h after birth, and CFOE was calculated. The mean gestational age was 27.9 (SD 2.39); 8 infants died (13.3%) and 7 developed IVH grade III-IV: 1 in the alive group and 6 in the deceased group (p < 0.001). The odds ratio for death was 1.08 (95% CI: 1.015-1.15, p = 0.016) for each 10 periods of rSO2 values <40% in the first 48 h, and 4.2 (95% CI: 1.27-14.05, p = 0.019) for SVCf values <40 ml/kg/m...Continue Reading

Citations

May 5, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·P KorčekG Naulaers
Aug 19, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Heike Rabe, Hector Rojas-Anaya
Dec 20, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ahmad Nizar Abdul AzizKhorshid Mohammad
Mar 7, 2020·The International Journal of Artificial Organs·Kiyonori ItoYoshiyuki Morishita
Jul 1, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Isabel Hui Xuan NgTopun Austin
Nov 25, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Taisuke KitanoYoshiyuki Morishita
Oct 8, 2019·British Journal of Haematology·Maria Saito-BenzMary J Berry
Mar 30, 2017·Frontiers in Pediatrics·Laura Marie Louise DixPetra Maria Anna Lemmers
Apr 17, 2020·Early Human Development·Peter KorčekZbyněk Straňák
Dec 15, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ignacio Oulego-ErrozAntonio Rodríguez-Núñez

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