Cerebral peak alpha frequency reflects average pain severity in a human model of sustained, musculoskeletal pain

Journal of Neurophysiology
Andrew J FurmanDavid A Seminowicz

Abstract

Heightened pain sensitivity, the amount of pain experienced in response to a noxious event, is a known risk factor for development of chronic pain. We have previously reported that pain-free, sensorimotor peak alpha frequency (PAF) is a reliable biomarker of pain sensitivity for thermal, prolonged pains lasting tens of minutes. To test whether PAF can provide information about pain sensitivity occurring over clinically relevant timescales (i.e., weeks), EEG was recorded before and while participants experienced a long-lasting pain model, repeated intramuscular injection of nerve growth factor (NGF), that produces progressively developing muscle pain for up to 21 days. We demonstrate that pain-free, sensorimotor PAF is negatively correlated with NGF pain sensitivity; increasingly slower PAF is associated with increasingly greater pain sensitivity. Furthermore, PAF remained stable following NGF injection, indicating that the presence of NGF pain for multiple weeks is not sufficient to induce the PAF slowing reported in chronic pain. In total, our results demonstrate that slower pain-free, sensorimotor PAF is associated with heightened sensitivity to a long-lasting musculoskeletal pain and also suggest that the apparent slowing of...Continue Reading

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Citations

Jun 28, 2020·Cerebral Cortex·Andrew J FurmanDavid A Seminowicz
Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Junseok A Kim, Karen D Davis
Jun 22, 2020·Experimental Brain Research·Simon J SummersLucy S Chipchase
Jan 5, 2021·Frontiers in Systems Neuroscience·Genevieve Z SteinerMike Armour
Feb 12, 2021·Journal of Neurophysiology·Junseok A Kim, Karen D Davis
Jun 29, 2021·The Journal of Pain : Official Journal of the American Pain Society·Enrico De MartinoThomas Graven-Nielsen
Oct 16, 2021·Lab Animal·Suzan MeijsWinnie Jensen

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