Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Tara M MadhyasthaThomas J Grabowski

Abstract

Cortical dysfunction in Parkinson's disease (PD) may be caused by disruption to ascending systems or by intrinsic cortical neuropathology. We introduce and conduct a joint analysis of metabolism and atrophy capable of identifying whether metabolic disruption occurs in mild PD without cortical atrophy, to determine the extent and spatial pattern of cortical involvement in mild PD. The design was observational, studying 23 cognitively normal participants with mild PD (mean Hoehn & Yahr stage 2) and 21 healthy controls. Cortical thickness (obtained from analysis of structural magnetic resonance imaging [MRI] with FreeSurfer) and cerebral perfusion measures (obtained from arterial spin labeling [ASL]) analyzed independently and then together in a joint multiple factorial analysis to identify spatial patterns of perfusion and cortical thickness. We identify a pattern of changes in perfusion and cortical thickness characterized by symmetric parietal cortical thinning and reduced precuneus perfusion, with relative preservation of thickness and perfusion in the anterior cingulate cortex (ACC), right prefrontal gyrus, and medial frontal gyrus. The expression of this pattern is correlated with motor system symptoms and speed of processin...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 1, 1974·Perceptual and Motor Skills·A A Weiss
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Shallice
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D EidelbergS Przedborski
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Aug 18, 2000·Immunopharmacology and Immunotoxicology·M Domingues-JuniorJ Palermo-Neto
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·G F WootenJ Patrie
Sep 1, 2004·Cell and Tissue Research·Heiko BraakKelly Del Tredici
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Jul 4, 2006·Journal of the Neurological Sciences·Heiko BraakKelly Del Tredici
Sep 22, 2007·Lancet Neurology·Thomas EckertDavid Eidelberg
Nov 11, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Phil Hyu LeeYoung-Sil An
Jan 7, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yilong MaDavid Eidelberg
Apr 29, 2010·Magnetic Resonance Imaging·Sina Aslan, Hanzhang Lu
Jun 5, 2010·Brain Pathology·G Stennis Watson, James B Leverenz
Sep 8, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas J MontineJing Zhang
Dec 28, 2010·NeuroImage·Thomas JubaultOury Monchi
Mar 15, 2011·Annals of Neurology·Min ShiJing Zhang
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Oct 29, 2011·NeuroImage·María A Fernández-SearaMaría A Pastor
Oct 6, 2012·Annals of Neurology·David J IrwinJohn Q Trojanowski
Nov 6, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Naroa Ibarretxe-BilbaoEduardo Tolosa
Mar 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Mojtaba ZareiMaria Jose Martí
Aug 1, 2013·Nature Reviews. Neuroscience·David J IrwinJohn Q Trojanowski
Aug 14, 2013·Journal of Parkinson's Disease·Brenna A CholertonJames B Leverenz

❮ Previous
Next ❯

Citations

Mar 9, 2017·Journal of Neural Transmission·Zoe Joanna SyrimiIrena Rektorova
Apr 6, 2017·Journal of Neural Transmission·Beatrice HeimKlaus Seppi
Apr 4, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Stéphane LehericyUNKNOWN International Parkinson and Movement Disorder Society (IPMDS)-Neuroimaging Study Group
Mar 16, 2017·Parkinsonism & Related Disorders·Stefano ZanigniCaterina Tonon
Nov 30, 2016·NeuroImage. Clinical·Peter BoordThomas J Grabowski
Dec 29, 2017·Neuroscience Bulletin·Zhen-Yang LiuJian Wang
Feb 5, 2019·Human Brain Mapping·Sara PonticorvoFabrizio Esposito
Dec 30, 2016·Brain and Behavior·Daniel O ClaassenSwati Rane
Mar 30, 2019·Therapeutic Advances in Neurological Disorders·Laura PelizzariFrancesca Baglio
Jul 14, 2020·Frontiers in Neurology·Laura PelizzariFrancesca Baglio
Dec 21, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K C BijuRobert A Clark
Apr 21, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Carme UribeCarme Junque
Sep 18, 2018·Assessment·Sally RichmondSarah Whittle
Aug 20, 2021·Brain Imaging and Behavior·Yichen ZhangRuiwang Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Chul Hyoung LyooMyung Sik Lee
Movement Disorders : Official Journal of the Movement Disorder Society
Roberta BiundoAngelo Antonini
Movement Disorders : Official Journal of the Movement Disorder Society
Bàrbara SeguraCarme Junque
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Campbell J Le HeronTim J Anderson
© 2022 Meta ULC. All rights reserved