Cerebral-perfusion-based single-photon emission computed tomography (SPECT) staging using NeuroGam® in patients with moyamoya disease

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Jai-Hyuck HanSang-Hoon Cha


Cerebral angiography (CA) is the gold standard for moyamoya disease (MMD) staging and diagnosis, but CA findings are not well correlated with clinical symptoms. The purpose of this study was to establish novel cerebral-perfusion-based staging for MMD that is well correlated with clinical symptoms. From 2010 to 2015, regional cerebrovascular reserve (rCVR) was examined by single-photon emission computed tomography (SPECT) using NeuroGam® (Segamicorp, Houston, TX, USA) in 30 patients (17 women, 13 men; 60 hemispheres; mean 42.0 years old [range 5-60 years old]) with MMD, which was diagnosed by CA and magnetic resonance angiography (MRA). Brain CT or brain magnetic resonance imaging (MRI) was used to evaluate neurological conditions such as transient ischemic attack (TIA), cerebral hemorrhage, and cerebral infarction. A novel staging system for MMD was developed by combining findings from CA, MRI, and SPECT with NeuroGam®. Our novel staging system was strongly associated with clinical symptoms. Twenty-two hemispheres out of 60 were categorized as stage I, 24 hemispheres were categorized as stage II, and 14 hemispheres were categorized as stage III. Hemispheres with higher scores exhibited a higher incidence of clinical symptoms. T...Continue Reading


Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I KannoI Sayama
Oct 1, 1984·Archives of Neurology·B L HolmanD H O'Leary
Jan 1, 1982·European Journal of Nuclear Medicine·P MagistrettiH Royal
Jan 1, 1983·Stroke; a Journal of Cerebral Circulation·J Suzuki, N Kodama
Feb 1, 1982·Journal of Computer Assisted Tomography·S TakeuchiJ Ito
Nov 1, 1994·Stroke; a Journal of Cerebral Circulation·K HoukinH Abe
Feb 1, 1997·Surgical Neurology·M Fukui
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R TakeuchiJ Konishi
Jul 11, 1998·Stroke; a Journal of Cerebral Circulation·T NariaiK Hirakawa
Oct 3, 1998·JAMA : the Journal of the American Medical Association·R L GrubbW J Powers
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T NariaiK Ohno
Jul 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoji TanakaKikuo Ohno
Sep 1, 2005·Cerebrovascular Diseases·Kiyohiro HoukinTakashi Yoshimoto
Oct 23, 2008·Lancet Neurology·Satoshi Kuroda, Kiyohiro Houkin
Mar 20, 2009·The New England Journal of Medicine·R Michael Scott, Edward R Smith
Apr 2, 2009·Neurosurgical Focus·Marco LeeGary K Steinberg
Mar 31, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Felix P KuhnNadia Khan

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