Cerebral perivascular nerves in subarachnoid hemorrhage. A histochemical and immunohistochemical study

Journal of Neurosurgery
H HaraB Weir

Abstract

The authors have studied the changes induced by subarachnoid hemorrhage (SAH) in the density and distribution of cerebral perivascular nerves in monkeys and rats. The SAH was induced in monkeys by placement of an autologous blood clot after opening the basal cisterns over the arteries of the circle of Willis on one side. In the rat study, SAH was induced by injection of autologous arterial blood into the cisterna magna. The nerves examined were adrenergic nerves, acetylcholinesterase (AChE)-containing nerves, vasoactive intestinal polypeptide (VIP)-like immunoreactive nerves, and substance P-like immunoreactive nerves. In the monkey study, all animals underwent baseline cerebral angiography, then had repeat angiography just before sacrifice on Day 2, 7, 28, or 70 after SAH. Two sham-operated monkeys underwent the surgical procedure without clot placement and were sacrificed on postoperative Day 7, after repeat angiography. Clot placement in monkeys reduced staining of all middle cerebral artery (MCA) perivascular nerves for between 2 and 28 days post-SAH. The number of stained nerve fibers of MCA's on the non-operated side was slightly reduced on Days 2 and 7 after SAH. Sham-operated monkeys showed a mild reduction of staining ...Continue Reading

References

Jul 1, 1979·Stroke; a Journal of Cerebral Circulation·F A SimeoneJ D Irvin
May 1, 1978·Stroke; a Journal of Cerebral Circulation·C R Benedict, A B Loach
Jan 1, 1978·Blood Vessels·W R Hume, J G Waterson
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·T J DelgadoN A Svendgaard
Jan 1, 1970·Transactions of the American Neurological Association·R A FraserJ L Pool
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·L EdvinssonB Sporrong
Oct 14, 1967·Nature·M StefaniniL Zamboni
Sep 1, 1970·Stroke; a Journal of Cerebral Circulation·R A FraserJ L Pool
Aug 1, 1971·Journal of Neurosurgery·S J Peerless, M G Yasargil
Jan 1, 1980·British Journal of Pharmacology·K P KlugmanC Rosendorff
Mar 1, 1983·Brain Research Bulletin·D M Jacobowitz, G J Creed
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·J YoshiokaR R Smith
Apr 1, 1981·Acta Physiologica Scandinavica·J J LarsenB Ottesen
Sep 1, 1958·Journal of Clinical Pathology·D J ASHLEY
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS

❮ Previous
Next ❯

Citations

May 24, 2006·Acta Neuropathologica·Yuji UedaJohn T Povlishock
Jan 1, 1995·Pharmacology & Therapeutics·F Dauphin, E T MacKenzie
Jan 1, 1993·Brain Research Bulletin·J T KellerM Zuccarello
Apr 13, 2002·Japanese Journal of Pharmacology·Richard SercombePhilippe Gomis
Sep 1, 1992·Journal of Neurosurgery·R M PlutaE H Oldfield
Apr 1, 1996·Journal of Neurosurgery·R M PlutaE H Oldfield
May 9, 2014·Journal of the Neurological Sciences·Ana Rodríguez-RodríguezFrancisco Murillo-Cabezas
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TanakaD A Dougherty
Mar 1, 1990·Stroke; a Journal of Cerebral Circulation·D W Busija, C W Leffler
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·R L Macdonald, B K Weir
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·M DebdiR Sercombe
Jan 1, 1993·Acta neurochirurgica·T Delgado-ZygmuntN A Svendgaard
Jan 1, 1992·Acta neurochirurgica·A PasqualinJ C Torner
Feb 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J M FindlayA Howarth
Feb 1, 1989·Annals of Neurology·M D LinnikM A Moskowitz

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
transmission electron microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.