Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Min He, Qulian Guo

Abstract

To explore the impact on cerebral protection of Trichostatin A (TSA) preconditioning in rats with middle cerebral artery occlusion (MCAO); the relationship between cerebral protection of TSA and interleukin-1 beta (IL-1β); and the impact of age on the mechanism of cerebral protection of TSA. The modified suture method was used to create stable a MCAO model. A total of 96 male SD rats were assigned randomly to four groups: a control group, a dimethyl sulfoxide (DMSO) preconditioned group, a low-dose (0.03 mg/kg) TSA-preconditioned group, and a high-dose (0.1 mg/kg) TSA-preconditioned group. Each group included four sub-groups for reperfusion for 6, 12, 24 and 48 hours, respectively, 6 rats per sub-group. An additional, eighteen healthy, male Sprague Dawley (SD) rats that received TSA preconditioning (0.1 mg/kg) were divided into three groups based on their age: young, mid-age, and old, One-way analysis of variance was used to compare the differences between groups, and the Spearman rank correlation was used to examine relationships between IL-1β concentrations in blood and cerebrospinal fluid and cerebral infarction volume. The cerebral infarction volume of rats in the high-dose TSA group was less than that of the other 3 groups...Continue Reading

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