Cerebral Reorganization after Hemispherectomy: A DTI Study

AJNR. American Journal of Neuroradiology
A MeodedA Poretti

Abstract

Hemispherectomy is a neurosurgical procedure to treat children with intractable seizures. Postsurgical improvement of cognitive and behavioral functions is observed in children after hemispherectomy suggesting plastic reorganization of the brain. Our aim was to characterize changes in DTI scalars in WM tracts of the remaining hemisphere in children after hemispherectomy, assess the associations between WM DTI scalars and age at the operation and time since the operation, and evaluate the changes in GM fractional anisotropy values in patients compared with controls. Patients with congenital or acquired neurologic diseases who required hemispherectomy and had high-quality postsurgical DTI data available were included in this study. Atlas- and voxel-based analyses of DTI raw data of the remaining hemisphere were performed. Fractional anisotropy and mean, axial, and radial diffusivity values were calculated for WM and GM regions. A linear regression model was used for correlation between DTI scalars and age at and time since the operation. Nineteen patients after hemispherectomy and 21 controls were included. In patients, a decrease in fractional anisotropy and axial diffusivity values and an increase in mean diffusivity and radial...Continue Reading

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Citations

Mar 24, 2016·Journal of the Neurological Sciences·Bilge ÖztoprakÖzlem Kayım Yıldız
Nov 4, 2017·Journal of Neurosurgery. Pediatrics·Anthony C WangJeffrey G Ojemann
Jun 21, 2018·Frontiers in Neurology·Cristina RosazzaFrancesco Ghielmetti
Jan 8, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Avner MeodedEric Jackson

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